Endocrine Abstracts

Introduction: Follicular thyroid cancer (FTC) accounts for 12% of differentiated thyroid cancers (DTC). It is frequently complicated by bone metastasis (BM), which impact quality of life (QOL) and decreases the 10-year survival rate to 13-21%.Case Report: A 53-year-old woman followed at the Pain Clinic for over 10 years for lower back pain, had been operated three years before due to lumbar disc herniation. Pain relapsed one year after surgery and was re...

Introduction: Central obesity and the consequent metabolic syndrome have global devastating effect on the health system due to their strong association with type 2 diabetes mellitus and cardiovascular disorder. There are contradictory results about the influence of insulin resistance and visceral adipose tissue on bone phenotype. The study was designed to evaluate the association between bone quality and bone mineral density (BMD) with bone marrow adipose tissue (MAT) as well ...

Background and aims: Obesity is a chronic multifactorial disease characterized by an excessive accumulation of body fat resulting from an imbalance between energy intake and caloric expenditure. Uncoupling protein 2 (UCP2) is located in the inner mitochondrial membrane and plays an important role in the regulation of energy expenditure. NLR family, pyrin domain-containing 3 (NLRP3) inflammasome seems to have a key role in obesity-induced inflammation through production of the ...

A 30-year-old man of Asian descent presented to the emergency department with recurrent episodes of sudden onset limb weakness and difficulty walking over a period of 3 years. Each episode resolved within 2–3 h and he had fully normal mobility in between episodes. He denied any visual, bulbar symptoms or other focal neurology. He had a 9 year history of Graves’ disease for which he had recently discontinued carbimazole therapy in preparation fo...

Some authors observed lower thyroid antibodies titers (AbT) in children than in the adult population. The aim of this work was to consider the prevalence of positive results in AbT and elevated TSH levels. We have considered AbT and TSH measurements in a large population. We divided samples in 7 age groups 0–18, 18–20, 20–40, 40–50, 50–60, 60–70 and >70 years old. Cut-off positivity for AbTg and AbTPO was 50 and for TSH was 10 mUI/ml.<p cl...

Introduction: Obesity is associated with lower serum 25-hydroxyvitamin D (25(OH)D) concentrations. A major explanatory hypothesis is that vitamin D is sequestered by adipose tissue. Another hypothesis is a decreased hepatic activation by 25-hydroxylase in obese individuals. Because adipose tissue has different characteristics and functions in different parts of the body an important question is whether serum 25(OH)D is more strongly related to visceral (VAT), hepatic, or total...

Thyroid cancer is one of the most frequent malignancies of the endocrine system, and its incidence is predicted to become the fourth leading cancer diagnosis by 2030. Among thyroid carcinomas, anaplastic thyroid cancer (ATC) is the most aggressive and lethal tumor, which grows very rapidly, invades adjacent tissues and metastasizes, causing death in 1 year from diagnosis. We recently showed that in thyroid cancer PATZ1 expression is downregulated compared to normal thyroid and...

Endocan has been reported as specific of endothelial tumor cells and was shown to be expressed by tip cells during angiogenesis process.The principal aims of the study are the assessment of immunohistochemical VEGF and Endocan expression in functioning and non functioning pNETs and the comparison of these markers with clinical features, Ki67 and TNM staging.We collected a total number of 79 pNETs surgical specimens for immunohistoc...

Background: Hypogonadism in men is associated with low muscle mass and force. Although, androgen replacement is an effective therapy, it can have undesirable side effects. Identifying the androgen regulated molecular mechanisms that increase muscle mass and function could lead to the identification of novel muscle-specific therapeutic targets to improve the clinical outcomes of muscle wasting diseases. In this study, we examined in mice the effects of orchidectomy (after 1, 7 ...

Hyperprolactinemia may cause bone loss in pre-menopausal women and men. Data on fractures are scanty and it is still unclear which is the skeletal impact of hyperprolactinemia in post-menopausal women. The aim of this study was to evaluate the prevalence of vertebral fractures in post-menopausal women with hyperprolactinemia.Forty post-menopausal women (median age 57 years, range: 47–81) with prolactin (PRL)-secreting adenoma and 119 control post-me...