Endocrine Abstracts

Background: Targeted therapy using phosphatidylinositol 3-kinase (PI3K) inhibitors has become widespread in the treatment of cancers. Although PI3K inhibitors raised concern about the alteration of glucose and lipid metabolism from animal studies, human clinical data have been rarely reported.Aim: We investigated the clinical manifestations, incidence of diabetes and its predictive factors in cancer patients who treated with PI3K inhibitors.<p class=...

Although the steroidogenesis in testis occur in a paracrine rather than in an endocrine, the comparative metabolic pathways between fetal and adult mice are not fully understood. Here, gas chromatography-mass spectrometry-based assay for profiling of 23 androgens, 7 estrogens, 13 corticoids, and 14 progestagens has been developed and applied to quantify their testis levels from both fetal and adult mice. Testis samples were purified with Oasis HLB solid-phase extraction and se...

Introduction: Type 2 diabetes has a relationship with fatty liver. Fatty liver can progress to liver fibrosis. This study examined relationship between liver fibrosis and diabetes-related complications in type 2 diabetic patients.Methods: This study analyzed data from the 2007 to 2015 the Korea National Health and Nutrition Examination Survey (KNHANES) in South Korea. Which included values of c-peptide, fasting blood sugar, AST, ALT, and platelet to calc...

Nonylphenol (NP), a member of alkylphenol family, has been widely used in both industry and household. NP is classified as an endocrine-disrupting chemical and is known to act as an agonist of the GPER (GPR30). The aim of this study was to address the two-generational effects of para-nonylphenol (NP) on the body weights, reproductive organ weights and histopathologies of ICR mice. We also test the potential reproductive toxicity of octylglucuronide (OG), a substitute candidate...

Uncontrolled hyperglycemia accelerates endothelial damage and vascular inflammation caused by proinflammatory cytokines including tumor necrosis factor α (TNFα), which leads to arteriosclerotic cardiovascular diseases. Glycogen synthase kinase 3β (GSK3β) is reported to mediate TNFα-stimulated nuclear factor-κB (NF-κB) activation and expression of vascular adhesion molecules. Although a few clinical trials have suggested that telmisartan, an a...

Uncontrolled hyperglycemia accelerates endothelial damage and vascular inflammation caused by proinflammatory cytokines including tumor necrosis factor α (TNFα), which leads to arteriosclerotic cardiovascular diseases. Glycogen synthase kinase 3β (GSK3β) is reported to mediate TNFα-stimulated nuclear factor-κB (NF-κB) activation and expression of vascular adhesion molecules. Although a few clinical trials have suggested that telmisartan, an a...

Objectives: Considerable evidence shows that increased serum calcium levels are associated with metabolic disorders, cardiovascular disease and increased mortality. This study investigated whether serum calcium, within a normal range, is significantly associated with serum fibrinogen and homocysteine, markers of increased cardiovascular disease risk in non-diabetic Korean subjects.Methods: A cross-sectional analysis was performed on 1096 subjects (mean a...

Objective: 18F-FDG-avid differentiated thyroid cancers (DTC) have been known to behave more aggressively, especially in metastatic sites (flip-flop phenomenon). However, the clinical behaviour of DTC detected incidentally by FDG–PET (PET incidentaloma) has been sparsely reported. We wanted to know whether flip–flop phenomenon is applicable in PET incidentalomas.Methods: 165 DTC patients who underwent thyroid surgery and had pre-operative FDG&#1...

Background and aims: Obesity is a global problem. Laparoscopic sleeve gastrectomy (LSG) was introduced in our hospital since 2008. This study aimed at reviewing the metabolic changes after LSG among Hong Kong Chinese in a regional hospital.Materials and methods: 47 patients who received LSG in our hospital from June 2008 to October 2012 were retrospectively reviewed. Change in body weight (BW) and glycaemic control up to 5 years were evaluated. Rate of r...

Background: Radiofrequency ablation has recently been used for the treatment of benign thyroid nodules, with outstanding results. However, in most related studies, smaller nodules (<2 cm) were included and the procedure was usually performed by a radiologist or surgeon. Therefore, this study evaluated the efficacy and safety of radiofrequency ablation for nodules >2 cm performed by an endocrinologist with several years of experience performing fine-needle aspiration cy...