Endocrine Abstracts

Immune checkpoints inhibitors have fundamentally changed the management of oncologic patients. These treatments consist of monoclonal antibodies directed against CTLA-4 (cytotoxic T-lymphocyte antigen 4), PD-1 (programmed cell death protein-1) and PD-L1 (one of its ligands). By blocking these receptors or ligands, the antibodies reverse the immune tolerance induced by the cancerous cell on the T-lymphocyte and favour lymphocytic reactivation and anti-tumor activity. Immune tol...

Background: Papillary thyroid carcinoma (PTC) is a well differentiated malignant tumour that usually has a good prognosis in vast majority of patients after thyroidectomy, suppressive hormonal, and radioiodine treatment. However 5–10% of PTC cases can develop local relapse and distant metastases.Purpose of study: To make a comparative morphological analysis of PTC in two groups of patients: i) with and ii) without local relapse (regional metastases)...

Diabetes type two is associated with greater bone mineral density (BMD) due to obesity although observed rapid bone loss over time could be explained with elevated chronic inflammation. The objective of this study was to investigate the relationship between central adiposity and hyperinsulinaemia as well as inflammation markers with vertebral and femoral BMD and bone turnover markers in postmenopausal women with type two diabetes. Femoral and vertebral BMD, osteocalcin, pyrili...

Introduction: Calcium transport is regulated by active transcellular and passive paracellular pathways which are responsible for calcium (re)absorption in the intestine and kidney. The activity of passive transport is determined by the permeability of tight junction. In general, the permeability of tight junction is inversely proportional with the expression of tight junction genes. Claudin and occludin among the tight junction genes are concerned directly with permeability of...

Introduction: Pseudohypoparathyroidism type la (PHP-1a) is an uncommon disorder that results from an inactivating mutation in the GNAS gene. It can present with resistance to several hormones, in addition to parathyroid hormone (PTH). A characteristic skeletal phenotype also results, referred to as Albright’s hereditary osteodystrophy, that occurs because of the crucial role of Gs-α signaling in the growth, differentiation, and structure of these tissues.<p class...

Introduction: Acromegaly and Waldenstrom’s macroglobulinaemia are two rare diseases (about 3–4 and 10 cases/million per year respectively), the association between them is even more infrequent, one case being reported in the available literature.Case report: We present the case of a 74-years-old female (I.I.) suffering with both diseases. In 1997 acromegaly diagnosed by dysmorphic syndrome, than in 2004 hormonal/imagistical investigations (GH a...

Hypercalcaemia is a common finding in numerous diseases processes but is non-specific to its cause. We report a case of a 55-year-old lady with known sarcoidosis who developed hypercalcaemia and elevated parathyroid hormone due to a parathyroid adenoma. Both these disease processes are independently associated with hypercalcamia, but it is unusual to have both in combination and difficult to establish which is the primary cause. In our case the diagnosis was complicated by a n...

Introduction: Loss of protective sensation, inflammation and trauma may lead in predisposed diabetics with peripheral neuropathy to Charcot foot.Methods: Regular foot screening enables identification of those individuals who are at highest risk for foot ulceration. Special attention must be paid to infection. Differentiation between osteomyelitis and Charcot arthropathy is mandatory, the two conditions may coexist. Basic conservative treatment for Charco...

Some studies reports the high prevalence of unsuspected hypercortisolism in high-risk populations.Aim: To evaluate the prevalence of undiagnosed hypercortisolism in patients with diabetes mellitus (DM), adrenal incidentaloma and obesity.Material and methods: We prospectively evaluated 30 DM patients (8 male, 22 female, 53.5 years old (18; 73), HbA1c-7.1% (5.6; 13.8)), 22 patients with adrenal incidentaloma (6 male, 16 female, 53.5 ...

Aim: A chemiluminescence enzyme immunoassay (CLEIA) for high-molecular-weight adiponectin (HMW-ADPN) was recently developed, and has been shown to be faster, more accurate and less expensive than conventional ELISA. In this study, we investigated the relationships between metabolic parameters and the HMW-ADPN level measured by CLEIA in a health check-up setting.Methods: Informed consent was obtained from 1036 male and 416 female Japanese, 40 to 71 years ...