Endocrine Abstracts

Introduction: Iodine is critical for thyroid morphology and function. On the one hand, iodine is a factor leading and permitting to origin of disturbances of thyroid follicular cells function, on the other hand, it’s therapeutic agent.Aim: The aim of the study was to evaluate iodine metabolism in different forms of hyperthyroidism and to analyze relationship between metabolism and thyroid size and function.Material and methods...

The role of ghrelin in the pathogenesis of acromegaly is doubtful. Ghrelin also regulates glucose and adipose tissue metabolism. It has not been demonstrated whether it contributes to the development of metabolic complications of acromegaly.Aim: The aim of the study was to assess: (1) whether serum concentrations of total and acyl ghrelin in patients with acromegaly differ in relation to coexisting metabolic complications (hypercholesterolemia, hyperinsu...

Background: Thyroid hemiagenesis (TH) is a rare inborn anomaly, occurring if one of the thyroid lobes fails to develop. Due to mostly asymptomatic course, it is usually detected incidentally, during investigation of concomitant abnormalities of the thyroid function or structure.Case report: A case of Graves’ hyperthyroidism following primary hypothyroidism due to Hashimoto’s thyroiditis (HT), accompanying a TH, is reported. The patient first pr...

Introduction: Ghrelin is known to strongly stimulate growth hormone release from the pituitary. It was also found to be produced locally in hypothalamus and anterior pituitary and in different types of pituitary adenomas. It’s been suggested that ghrelin synthesized locally in hypothalamo–pituitary area or within pituitary tumours can be an important factor contributing to pituitary tumorogenesis.Aim: The aim of the study was the immunohistoche...

Introduction: Hyperthyroidism is one of frequently encountered clinical syndromes appearing in about 2% of adult population. The aim of this study was to evaluate the efficacy of radioiodine treatment in relation to the form of hyperthyroidism.Material and methods: The study investigated 300 patients: 150 with Graves’ disease and 150 with a toxic adenoma goiter (109 with a solitary nodule and 41 with a multinodular goiter). In all the cases, the est...

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly of unclear importance. The aim of the study is to describe clinical, hormonal and autoimmunological profile of patients with TH.Material and methods: The studied group consisted of 20 subjects (4 men), diagnosed of having TH at the age from 15 to 63. Laboratory tests, including measurement of serum concentration of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free tri...

Amiodarone is frequently used in cardiac patients but has side effects which effects the thyroid due to its high iodine content. The use of radioiodine in AIH with low iodine uptake is controversial. In these patients therapeutic choices for refractory cases include either: surgery, antithyroid drugs, or glucocorticosteriods.What are the treatment choices in elderly patients which can’t be operated on, agranulocytosis is present, or have toxic liver...

Introduction: Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, combined together, under the name of MELAS syndrome, constitute one of the mitochondrial genetic diseases with dominant progressive neurodegenerative symptoms. Although nervous system involvement is often the first manifestation of the disease, during the course of the disorder, patient can develop a wide spectrum of endocrine disorders ranging from GH deficiency and hypoparathyroi...

Introduction: Acromegaly with normal IGF-1level is rarely diagnosed and is difficult to recognize. In acromegalic pa-tients with poorly controlled diabetes, malnutrition, hepatic injury, hepatic congestion due to heart fail-ure, inflammatory diseases, renal dysfunction, and malignant neoplasm, IGF-1 synthesis is inhibited and thus in such cases normal IGF-1 levels may be observed. The aim of the study is to present a rare case of a patient with acromegaly and normal IGF-1 leve...

Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) overexpression was reported in many autoimmune diseases. We have also found NAMPT overexpression in leukocytes of patients with Graves’ orbitopathy. Therefore, we aimed to analyze NAMPT expression level in thyroid gland of patients with Graves’ disease with orbitopathy and without orbitopathy, and in healthy thyroid gland. We have analyzed 80 thyroid tissue samples of patients who underwent th...