Endocrine Abstracts

IntroductionAcromegaly is a chronic, slowly progressing disease caused in most cases by growth hormone (GH)- producing pituitary neuroendocrine tumors (PitNETs). This rare disorder is associated with a spectrum of various clinical manifestations and treatment outcomes differ between patients. The aim of this study was to evaluate the impact of age at the onset of symptoms and sex on clinical features, comorbidities, biochemical status at the diagnosis, a...

Primary thyroid lymphoma (PTL) is a rare disorder, representing merely 1-5% of all thyroid malignancies, 1-2% of extranodal lymphomas and 3% of non-Hodgkin’s lymphomas. It affects mainly women. PTL incidence is low in individuals younger than 40 years old. The most common clinical presentation of PTL is a palpable mass in the neck. It may be accompanied by other symptoms: dysphagia, dyspnea, and hoarseness. Diffuse B-cell lymphoma (DLBCL), is the most common pathological ...

Introduction: It’s known that type 2 diabetes is an independent risk factor for cardiovascular disease. Osteoprotegerin (OPG), a glycoprotein secreted mainly by osteoblasts, is also produced by heart muscle and vessels. Its role in the pathogenesis of atherosclerosis and future cardiovascular events is still discussed.Material and methods: The study was conducted in 113 patients (48 F, 65 M) with type 2 diabetes mellitus (DM2) and coronary heart dis...

Irisin is a recently reported, widely discussed new adipo-myokin secreted mainly by muscle tissue. It is a cleaved and secreted part of fibronectin type III domain containing 5, encoded by the FNDC5 gene. Some of the previously published studies claim that alterations of irisin levels in patients affected by thyroid diseases may be connected mainly with accompanying myopathy. However, to date it has not been evaluated, whether the changes in expression of FNDC5</e...

Introduction: Many original research studies describes significant impact of thyroid hormones on muscle tissue. Hypo- and hyperthyroidism cause both functional and structural damage of muscles presented by many signs and symptoms of thyroid myopathy. Thus, it is interesting to compare the impact of thyroid dysfunction on hormones secreted by muscles – myokines.Aim: The main goal of the project is to assess serum concentration of three myokines &#150...

Introduction: In years 1996–2000, the predominance of papillary thyroid carcinoma (PTC) (70.3%) compared to follicular thyroid carcinoma (FTC; 27.0%) and medullary thyroid carcinoma (MTC; 2.7%) was observed in our region. AIT coexisted in 1 PTC (2.7% of all cancers and 3.8% in PTC group).Aim: The aim of retrospective study was to analyze the coexistence of AIT and TC in years 2001-2015 in relation to years 1996–2000.Mater...

Introduction: It is known that type 2 diabetes increases the risk of cardiovascular disease. Fetuin-A is a multifunctional serum glycoprotein and its role in the pathogenesis of type 2 diabetes, atherosclerosis and cardiovascular disease is still discussed.Material and methods: The study was conducted in 36 patients (12 F and 24 M) with type 2 diabetes mellitus (DM2) and acute coronary syndrome (ACS), aged mean 70.22±7.62. The group was divided into...

Introduction: It’s known that type 2 diabetes increases the risk of cardiovascular disease. Silent myocardial ischemia occurs frequently in diabetics and may result in more severe coronary artery disease. Osteoprotegerin (OPG) is a glycoprotein secreted mainly by osteoblasts but it’s also produced by heart muscle. Its role in the pathogenesis of type 2 diabetes, atherosclerosis and future cardiovascular events is still discussed.Material and me...

Introduction: Neuroendocrine cancer of the ampulla of Vater area belongs to the most rare GEP-neuroendocrine tumors (NET). In the literature, there are few reports of extremely malignant course of this cancer. Among 242 patients with NET from the Department of Endocrinology in 2009–2013, 58 pancreatic NET were discovered, among which seven patients had neuroendocrine cancer of the ampulla of Vater. The aim of this study was to determine the clinical characteristics, stagi...

Introduction: Radioiodine therapy (RIT) in patients with Graves’ disease (GD) and orbitopathy (GO) is still controversial, especially in smokers, due to the risk of exacerbation of ophthalmologic symptoms.Aim: To evaluate the effect of RIT in smoking and non-smoking patients with mild GO in a 6-month follow-up.Patients and methods: We examined 26 smoking and 25 non-smoking patients, matched for age and gender, presenting hyper...