Searchable abstracts of presentations at key conferences in endocrinology

ea0073yi11 | Young Investigator Awards | ECE2021

Gβγ-mediated signaling regulates NIS abundance at the plasma membrane

Márcia Faria , João Bugalho Maria , Paulo Matos , Luísa Silva Ana

IntroductionThe Sodium Iodide Symporter (NIS) is responsible for the active transport of iodide into thyroid cells. Most of differentiated thyroid carcinomas (TC) retain the functional expression of NIS, which allows the use of radioiodide (RAI) as the systemic treatment of choice for metastatic disease. Still, a significant proportion of patients with advanced thyroid cancer fail to respond to RAI therapy (refractory-TC), which makes their management ve...

ea0073pep14.1 | Presented ePosters 14: COVID-19 | ECE2021

Is initial hypocalcemia related to poorer outcomes in COVID-19 patients?

Alves Helena , Ferreira Marta Almeida , Almeida Lucia , Correia Sara , Ramalho Diogo , João Oliveira Maria

IntroductionAlthough most patients with COVID-19 have mild symptoms, some develop severe manifestations of the disease, leading to hospitalization and death. Previous studies reported that calcium played a central role in viral infections and replicative mechanisms of SARS-CoV. Hypocalcemia is a common finding among these patients. The aim of this study was to investigate the prevalence of hypocalcemia in a population of COVID-19 patients and to evaluate...

ea0073aep48 | Adrenal and Cardiovascular Endocrinology | ECE2021

Lipid paradox in acute myocardial infarction

Correia Sara , Ramalho Diogo , Almeida Lucia , Alves Helena , Melo Gustavo , Maria João Oliveira

IntroductionSome studies have shown low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were significantly lower in high-Killip (III + IV) patients compared with low-Killip (I + II) patients and in those who died after acute myocardial infarction (AMI) compared with those who survived beyond 30 days, which they called lipid paradox. Elevated levels of LDL and triglycerides are important risk factors for cardiovascular disease, ...

ea0073aep107 | Calcium and Bone | ECE2021

New variant of the casr gene (c.2459c > t) associated with primary hypoparathyrodism – a case report

Lavrador Mariana , Lages Adriana , Bárbara Araújo , Luísa Barros , Paiva Isabel

BackgroundAutosomal dominant hypocalcaemia, caused by either inherited or de novo mutations in calcium-sensing receptor gene (CASR), is biochemically characterized by the presence of hypocalcaemia, hypercalciuria and inappropriately low levels of PTH. Receptor-activating mutations induce an increase sensitivity to calcium by parathyroid and renal cells, leading to suppression of PTH synthesis and consequently hypocalcaemia. Clinical manifestations are va...

ea0073aep168 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Use of the thrombolysis in myocardial infarction risk score for heart failure in diabetes in a type 2 diabetes mellitus outpatient population

Ramalho Diogo , Correia Sara , Almeida Lucia , Alves Helena , Melo Gustavo , Maria João Oliveira

BackgroundType 2 Diabetes Mellitus (T2DM) and Heart Failure (HF) are two directly related diseases associated with considerable morbimortality. The prevalence of HF in T2DM populations is up to 20%, 4 times higher than the general population. Additionally, health-related quality of life, hospitalizations for HF (HHF) and mortality risk are more common when both are present. Hence, HHF risk assessment in T2DM patients may lead to prompt preventive interve...

ea0073aep228 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Association of IDO polymorphism with oxidative status, metabolic control and inflammation in patients with type 2 diabetes mellitus

Neves Marta , Bicho Manuel , Santos Ana Carolina , João F. Raposo , Valente Ana

IntroductionThe Indoleamine 2.3-dioxygenase (IDO) is an enzyme involved in tryptophan metabolism, encoded by the IDO1 gene in humans. In Caucasians, the rs9657182 polymorphism of IDO gene was found to be associated with neurobehavioral complications, especially depression. Several studies in Type 2 Diabetes Mellitus (T2DM) describe psychological factors as barriers to the successful implementation of a healthy eating plan. According to our knowledge ther...

ea0073ep151 | Pituitary and Neuroendocrinology | ECE2021

Fasting glucose and other metabolic features of 17 Brazilian women with microprolactinomas

Botelho Mariana , Sousa Rafaela , João Nascimento , Lamounier Filho Adilson , Naliato Erika , Violante Alice

IntroductionAmong other organic functions, Prolactin (PRL) can influence metabolism.AimTo evaluate basal glucose metabolism in women with prolactinoma, according to menstrual cycle, presence of hyperprolactinemia, and dopamine agonist (DA) treatment.Material and methodsCross-sectional study of 17 women with microprolactinoma and 11 healthy controls. Variables eval...

ea0070aep817 | Reproductive and Developmental Endocrinology | ECE2020

Hutchinson – gilford progeria syndrome – a portuguese rare case

Catarino Diana , Bastos Margarida , Ribeiro Cristina , Fadiga Lucia , Silva Diana , Guiomar Joana , Lavrador Mariana , Vieira Inês , Araújo Cátia , Araújo Bárbara , Dinis Isabel , Mirante Alice , Paiva Isabel

Introduction: Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare disease (1:4 million) characterized by a fatal premature aging. There are 162 cases worldwide, five of them in Portugal. It is caused by a sporadic autosomal dominant mutation in LMNA gene that encodes an abnormal variant of the laminin-A protein, named progerin. Although most babies born looking healthy, they begin to display some characteristics of Progeria around 18–24 months of life. The ear...

ea0070ep43 | Adrenal and Cardiovascular Endocrinology | ECE2020

Pericarditis complicated with cardiac tamponade and Addison disease – A case report

Lavrador Mariana , Cardoso Luís , Catarino Diana , Fadiga Lúcia , Silva Diana , Guiomar Joana , Vieira Inês , Araújo Bárbara , Araújo Cátia , Barros Luísa , Paiva Isabel

Introduction: Addison Disease is a rare condition with an estimated incidence in the developed world of 0.8 cases per 100 000 population. It is associated with relevant morbidity and mortality rates, but once the diagnosis is made it can be easily managed. When Addison Disease is associated with other autoimmune diseases, the diagnosis of polyglandular autoimmune syndrome can be set. The recognition of symptoms and signs can be challenging and clinicians should be aware of aty...

ea0070ep264 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hearing complications in diabetes – A clinical case

Ivo Catarina , Duarte Vitória , Veríssimo David , Silva João , Costa Eurico , Lopes Luís , Passos Dolores , Matos Teresa , Jácome de Castro João , Marcelino Mafalda

Introduction: Malignant or necrotizing external otitis (MEO) is an invasive infection between external auditory canal and skull base. It is more frequent in elderly and in diabetic patients or with compromised immune system. As MEO advance osteomyelitis can developed. It is a severe and potential mortal complication of external otitis (EO).Clinical case: 78 years old man with history of type2 diabetes (good metabolic control) and right ear external otiti...