Endocrine Abstracts

IntroductionParathyromatosis is a potential cause of recurrent hyperparathyroidism, of rare etiology, described as multiple nodules of hyperfunctioning benign parathyroid tissue, it constitutes less than 1% of the cases of recurrent hyperparathyroidism and since its description in 1975, less than 40 cases have been reported Worldwide. The presentation in primary hyperparathyroidism is extremely rare, with around 20 cases reported in the English literatur...

Background and aimMajor depressive disorder (MDD) is one of the common mental disorder that affect more than 350 million subjects. MDD has been reported to be associated with systemic inflammation and obesity. However, there are no data that relate adipose tissue (AT) inflammation to MDD. The analysis of inflammatory markers in AT could pave the way to clarify the potential association between MDD and obesity. For this reason, the aim of our study was to...

IntroductionGastrointestinal adverse effects such as nausea and vomiting are widely described for GLP-1 receptor agonists (arGLP-1). We highlight Semaglutide, a drug that needs to start its administration at a reduced dose, to be able to increase the dose later with better tolerance and adherence of the patient. Not doing it this way can lead the patient to have serious adverse effects such as incoercible vomiting or profuse diarrhea that entails serious...

Background: Vitamin D deficiency is a worldwide health issue that affects more than one billion people. Few guidelines assess optimal dosing of vitamin D in general population, and although there is no international consensus, the optimum dosing for vitamin D3 and mainly calcifediol is not known.Objective(s): To assess the efficacy of calcifediol in the treatment of vitamin D deficiency, compared with therapeutic guidelines recommendations for cholecalci...

Introduction: Parathyroid adenoma is the most frequent cause of primary hyperparathyroidism (PHPT). In recent years minimally invasive surgical techniques have challenged the traditional bilateral neck exploration. There are different imaging techniques for preoperative location of parathyroid adenomas. In this study the authors review the role of Doppler ultrasound focusing on its safety, availability and affordability.Aim: To evaluate the role of Doppl...

Background: Total 25 hydroxyvitamin D (25(OH)D) and total 1.25 dihydroxyvitamin D (1.25(OH)2D) are associated with all-cause mortality. The free hormone hypothesis postulates that only the free vitamin D fraction can exert its biological function. Recently some studies suggested that free 25(OH)D levels might be a better predictor for clinical outcomes, including mortality.Objective: To study the association between total and free 25(OH)D and ...

Objective: To understand the factors associated with changes in thyroid nodule volume with previous benign citology.Material and Methods: This is a prospective single-center observational study. We included patients with a benign citology from March/2016 to May/2018 and ultrasound follow-up after 12–24 months. Initially we determined the nodule size (volume in ml), and its risk of malignancy was classified according to ATA 2015 criteria. Volume cha...

Neoplastic thyroid diseases (multinodular goiter (MNG), follicular adenoma, differentiated (DTC) and undifferentiated thyroid carcinoma) have a higher incidence in women than in men. In fact, in the last ten years, DTC is the only cancer increasing the frequency in women, with an incidence similar to ovarian carcinoma or lymphomas.TGFb is a secreted factor important in the normal function of the thyrocyte. It has two independent actions: a fast antiproli...

Background: The association between low testosterone (T) and higher mortality in men remains controversial. Most studies focus only on the association between total T (TT) and mortality. While TT declines with age, free T (FT) shows a greater fall, due to the rise in SHBG. Moreover, also sexual dysfunction, often co-existing with low T, has been associated with mortality in ageing men.Objective: To study the interrelationships between ...

IntroductionDenosumab (Dab) withdrawal is associated with a quick loss in bone mineral density (BMD) and a high risk of multiple vertebral fractures. It is still not stablished which strategy best prevents BMD loss after Dab discontinuation.AimCompare the use of bisphosphonates for one year after Dab withdrawal versus a tapering Dab regimen in terms of BMD and fracture occurrence.Method...