Endocrine Abstracts

Introduction: G protein coupled receptor dimerization is proposed to have great impact on receptor signaling. Allosteric communication between the protomers of a dimer can alter ligand binding, receptor conformation and the interactions with different effector proteins. Although the concept of intradimeric interactions is widely accepted, the molecular mechanism behind them is not clearly understood. In this study we investigated the allosteric interactions within the type I a...

Introduction: While most common aetiologies accounting for hyperthyroidism are straightforward and respond predictably to treatment, a subset provides diagnostic or therapeutic challenge. We report such a case.Case report: A 26-year-old Afro-Caribbean male presented with symptoms of thyrotoxicosis. FT4 was 50 (12–20 pmol/l), FT3 11.5 (3–8 pmol/l) and TSH 5.38 (0.27–4.20 mU/l). He had diffuse non-tender thyromegaly without eye signs. Thyroi...

Preclinical and clinical studies suggest that whey protein intake can ameliorate postprandial glucose control and potentiate insulin release in both type-2 diabetic patients and healthy subjects.Most likely, the insulinotropic effect of whey occurs by multiple pathways, including the potentiation of incretin activity through inhibition of DPP-4 in the proximal bowel, with the outcome of increasing intact incretin levels.During last...

Background and Aims: Diabetes causes immeasurable personal suffering and costs to the society, though diabetes and its complications are largely preventable. There are proven, affordable preventions available, that can stop or delay diabetes/complication development. Political Declaration adopted by UNO stresses importance of educational measures to promote health education and literacy. IMAGE Project/Toolkit on Type 2 Diabetes Prevention in Europe outlines education as corner...

Bisphenol A (BPA) is an endocrine disruptor (ED) used as plasticiser present in plastic products of daily use. The leakage of BPA monomer into food, drinks represents the ubiquitous exposure to the general population. BPA stimulatory effect on breast cancer cells growth in vitro and increased incidence of hormone dependent malignancies suspected BPA from carcinogenic effect.The aim of this study was to investigate the effects of BPA alone and in t...

Objective: Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. In the present study, we aimed to examine the complex interplay between BPA exposure, fat mass, fat-free mass, serum estradiol, leptin, osteocalcin levels and BMDs in a group of premenopausal women.Methods: A total of 246 Chinese premenopausal women aged 20 years and older with regular menstrual cycles were investigated...

IGF1 represent an important key player in several physiologic process, so it can be implicated in different pathologies among delays of growth. A comparative study was realized comparing a group of healthy Algerian children of normal size (n: 266) and a group presenting a GH deficiency (GHD n: 107)to a group of healthy westerners children of normal size(Serie of ROSENFIELD).The results are as follows: Before the age of 04 years, there is a ...

Idiopathic hypogonadotropic hypogonadism (IHH) is caused by an isolated defect in GnRH release or action and classified as the Kallmann syndrome with associated anosmia or normosmic IHH in the presence of a normal sense of smell. Patients with IHH have absent or incomplete sexual maturation and infertility. Usually long term GnRH or gonadotropin therapy in these patients can induce spermatogenesis and puberty and is followed by testosterone therapy to maintain normal virilizat...

About 8–10% of erectile dysfunction (ED) is caused by hormonal causes, but in men over 65 years testosterone deficiency due to aging seems to play important role. In population of Polish men with relative poor health status, the prevalence of testosterone deficiency in elderly men with ED is probably higher. We evaluated the prevalence of low and low-normal testosterone levels in men with ED in population of Polish men over 65 years.Material and met...

Energy homeostasis is controlled by neural, endocrine and adipocyte factors and CNS plays a key role in this control. We have previously observed that ovariectomized (OVX) rats treated with estradiol have lower body weight gain associated with an increased hypothalamic CRF mRNA expression. We investigated the role of CRF on activation of hypothalamic CART neurons by leptin in estradiol-treated OVX rats. Female Wistar rats (200–250 g) were subjected to both OVX and cannula...