Endocrine Abstracts

Background: Pancreatic neuroendocrine neoplasms (panNENs) are heterogeneous, with grade (G) defined by Ki67 proliferation index (<3% G1, 3-20% G2, >20% G3) or mitotic rate. The G3 NEN subgroup is further divided into well differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NEC). Grade progression can occur over time, with low-to-high grade progression (L-to-H; G1/2 to G3) the most clinically relevant form. It is associated w...

Background: The epidemiology of typical (TC) and atypical carcinoid (AC) bronchopulmonary neuroendocrine tumors (pulmNETs) is not well understood. We aim to describe the incidence of pulmNETs and differences by sex and race and ethnicity (R&E) in the diverse state of California.Methods: All patients with malignant pulmNETs diagnosed from 1992-2019 in the population-based California Cancer Registry were identified by histology (ICD-O-3 code 8240 for T...

Introduction: Primary hyperparathyroidism (PHPT) is a state of increased bone turnover that can result in secondary osteoporosis. Antiresorptive treatment can be used to preserve bone mineral density (BMD). We compared the impact of zoledronate and denosumab on bone-related biochemical parameters.Methods: We analyzed interim data from our ongoing randomized trial on osteoporotic postmenopausal women with PHPT who are being treated with either zoledronate...

Background: Tirzepatide is a GLP-1/GIP co-agonist treatment for type 2 diabetes. Participants in the SURPASS trials were GLP-1RA naïve, but in clinical practice many patients are switched from other GLP-1RAs.Aims: To explore effects of prior GLP-1RA treatment on tirzepatide therapy outcomes.Methods: Review of clinical data from an outpatient Diabetes centre. Adults with 6 months follow-up post tirzepatide initiation were inclu...

Introduction: Endometriosis is a complex reproductive disease without clear etiology, thought to be on the increase, and possibly related to endocrine disruptor (EDs) exposure such as PCBs, dioxins, phthalates, or pesticides. It is part of a national project on reproductive health indicators related to EDs in France. We aimed to build a nationwide indicator of endometriosis incidence based on routinely collected data, usable to study temporal and spatial trends for environment...

This abstract has been withdrawn at the request of the first author and Imperial College London. 08/06/2022...

The brain plays a crucial role in maintaining the body’s energy needs, a process involving the activity of a group of hypothalamic neurons that express the neuropeptidergic marker pro-opiomelanocortin (POMC). POMC neuronal dysfunction can cause obesity and its associated metabolic sequelae. However, this population of neurons is highly diverse at a molecular and functional level, and whether or not such heterogeneity is implicated in disease establishment or progression h...

Background: Weight gain in type 1 diabetes (T1D) patients has become a clinical problem due to less strict diets and more stringent glycemic targets. Thus, the number of overweight T1D in the USA increased from 3.4% in 1988 to 22.7% in 2007. Hyperinsulinism is involved in the genesis of obesity but in T1D, the impact of insulin therapy in weight gain is not established. Islet transplantation, now reimbursed in France, makes it possible to interrupt insulin. The aim of this wor...

Case History: A 61-year-old Caucasian female from Ukraine presented with severe hypercalcaemia following routine blood tests performed by the GP. She reported symptoms of back pain and joint pains. She had renal stones 10 years prior. No history of thiazide or lithium use. No red flags; no change in appetite or weight loss. There was no familial history of Multiple Endocrine Neoplasia (MEN). Examination of her neck, cardiorespiratory, abdomen and breasts were normal. <p cl...

Heterozygote mutations of the gene CDC73 are responsible for 3 types of parathyroid diseases: familial hyperparathyroidism, parathyroid carcinoma, hyperparathyroidism-jaw tumor syndrome (and uterine or kidney lesions). The goal of our study was to describe the phenotype associated with the deletion of the 3rd exon of CDC73 found in a large family.Patients: We have medical records for 25 patients of a large family composed of 44 individu...