Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) affects 10-15% of women worldwide, depending on the population and the diagnostic criteria used. The diagnostic criteria include clinical and/or biochemical hyperandrogenism, oligo/anovulation, and polycystic morphologic appearance of the ovaries. PCOS is associated with high risk of obesity, diabetes, cardiovascular diseases, and a wide spectrum of mental health disorders. Despite international recommendations, there is still lac...

Background: Cardiovascular diseases (CVD) present sex specific characteristics, suggesting sex-hormones playing a role in the pathophysiology of CVDs. Hyperandrogenemia (HA) is a common condition in fertile age women but whether HA is a risk factor for CVD is still controversial.Aims: To clarify the association of HA with the development of hypertension and CVDs in women.Study population and methods: A general population-based birt...

Background: Prostate cancer is a major global challenge due to the increasing number of aging population and frequency of diagnosis. During the past decade new treatments have been targeted to the androgen signaling axis either by inhibiting the binding of androgens to androgen receptor (AR) and AR nuclear translocation, or by inhibiting androgen production via CYP17A1 enzyme. Despite the significant progress on the research and new therapies, CRPC is still incurable and there...

Objective: To report a rare cause of ectopic adrenocorticotropic hormone (ACTH) secretion leading to Cushing syndrome.Methods: We describe the clinical presentation and management of a case of Cushing syndrome attributable to ectopic ACTH secretion from small cell cancer of the prostate.Results: In a 74-year-old man developed hypocalemia and heart failure. He was found to have severe hypokalemia (serum potassium, 2.37 mEq/l). Hormo...

Introduction: Autoimmunity is an important etiological factor of premature ovarian insufficiency (POI, menopause <40 years). It has been estimated that 4-50 % of POI cases are of autoimmune origin. Only a few studies, with sample sizes of dozens to hundreds POI cases, have investigated the prevalence of autoimmune diseases in women with POI. We aimed to assess in an essentially larger data set the prevalence of severe autoimmune diseases treated in tertiary care prior to P...

Introduction: Small-group teaching (SGT) has been widely adopted in medical education to promote problem-based learning and enhance the process of deep learning. Simulation via Instant Messaging - Birmingham Advance (SIMBA) is a simulation-based learning approach using WhatsApp and Zoom to increase participants’ confidence in managing various clinical scenarios.Aim: To investigate whether SIMBA provided similar knowledge and experiences as compared ...

Background: Women with polycystic ovary syndrome (PCOS) experience increased weight gain during life, thus weight management and preventing weight gain should be the first line treatment. Weight loss is usually self-initiated because practical support for weight management is often limited or even lacking. Perception of overweight is considered an important prerequisite for weight loss attempts, although there is no prior research regarding women with PCOS. The main aim of the...

Introduction : Polycystic ovary syndrome (PCOS) is associated with broad reproductive, metabolic and psychological complications, as well as significant heterogeneity in presentation between and within individuals across the lifespan. Therefore, there is a need for a multidisciplinary approach. A model of care (MoC) is conceptualised as an overarching provision of care that is codesigned with end-users and aligns with evidence-based practice and defined standards. The internat...

The significance of hyperandrogenism (HA) as a metabolic risk factor in women is controversial. HA can be defined as either clinical (hirsutism) or biochemical (elevated androgen levels). We aimed to investigate whether HA at age 31 associates with metabolic syndrome (MetS), type 2 diabetes mellitus (DM2) or carotid intima media thickness (CIMT) by age 46. In a prospective, general population-based follow-up birth cohort (n=5889 women) blood samples were collected at ...

Primary adrenal lymphoma(PAL) is very rare and constitutes <1% of cases of extranodal lymphomas. Most common subtype of PAL is diffuse large B cell lymphoma. A 46-year-old male patient without any underlying disease was admitted to our hospital with a complaint of bilateral back pain, cough and fever. His laboratory tests revealed a hemoglobin: 5 g/dl (14–17.5), white blood cell: 3.8 103/µl (4.4–11.3), platelet: 111 103/µl (130&#...