Endocrine Abstracts

Introduction: Refined carbohydrates which substitute the staple diet in most cultures may exaggerate postprandial responses in term of insulin and free fatty acid levels. These changes may herald the onset of metabolic syndrome and diabetes among those at high risk of these diseases.Objectives: To determine the postprandial insulin and free fatty acids levels in healthy subjects after the consumption of two different breakfast meals, Mediterranean-like v...

Background and aims: This study was done to predict renal impairment in type 2 diabetic patients with normo or microalbuminuria by detection of serum cystatin C, serum and urinary TGF-β levels.Material and methods: Seventy-eight patients were categorized into four groups depending on urinary albumin excretion and eGFR: eGFR <60 ml/min per 1.73 m2 with normoalbuminuria in group 1; eGFR was <60 or >60 ml/min per 1.73 m2</su...

One of the most clinical characteristic of Turner’s syndrome is the final short stature.In order to cure this handicap, several teams were interested to treat these patients by the GH.We report two cases of Turner syndrome associated with GH deficiency.In the first, a 17 years old girl, having a delayed growth lower than −4 S.D. associated with delayed puberty and dysmorphic syndrome...

Object of the study: To evaluate total testosterone (TT) levels in healthy young men and determine its possible influence on metabolic syndrome risk factors.Materials and methods: One hundred and twenty-six practically healthy young men, mean age 20.16±1.42 years old (18–29) were included in the study. Individuals with any clinical manifestations suspicious for hypogonadism, chronic liver and kidney diseases in the anamnesis or receiving any ki...

Objective: To investigate whether genetic variants in the glucocorticoid receptor (GR) and corticotropin releasing hormone receptor 1 (CRHR1) genes are associated with increased susceptibility for postnatal depression (PND).Methods: A prospective longitudinal cohort study at University Hospital, Coventry, England. Two hundred pregnant women were recruited and assessed for PND using the Edinburgh postnatal depression score (EPDS) upon recruitment and agai...

Prevalence of obesity in children and adolescents is reaching epidemic proportions. It is followed by the increase in incidence of type 2 diabetes (DM2) and dyslipidemia, and both disorders are risk factors of cardiovascular complications.Aim: The aim was to define the prevalence of impaired glucose tolerance (IGT), DM2, hypercholesterolemia and hypertriglyceridemia in overweight children and adolescents in Croatia.Subjects and met...

Instruction: Most of cases reported before who were detected by FT4 or T4 newborn screening are, TSH and GH deficiency or CNS anomalies, and their hypothyroidism is mild. We report two cases of sever congenital hypothyroidism with TSH and Prolactin (PRL) deficiency, detected by TSH and FT4 screening.Case report: Case 1. K.W. boy, was born at 38 gestations, weighted 3.17 kg. Thyroid function at 5 days of age was TSH 5.6 mU...

Background: One in 10–30 women in general population has Hashimoto’s (chronic) thyroiditis. Development of thyroid dysfunction depends on age. The ratio of woman around 50 with TSH elevation is 10% in general population. Menopause occurs at this age for most women. Many symptoms of hypothyroid state are similar to symptoms of menopause except hot flashes and night sweats. We analyzed the relationship of Hashimoto’s disease and menopausal symptoms.<p class="a...

Context: Recombinant human GH (rhGH) is indicated for the treatment of adult subjects with GH deficiency (GHD). However, conflicting data are available on the efficacy of rhGH treatment in elderly GHD patients.Objective: To assess the efficacy of rhGH treatment in elderly GHD subjects.Methods: We searched PubMed, Cochrane Library, Web of Science, and EMBASE.Study selection: Eligible studies included GHD patie...

Early events in activated by adrenaline (10−6 M) and phenylephrine (10−5M) single hepatocytes of rat have been investigated by quantitative image microfluorometry and microspectrofluorometry. Membrane potential-sensitive cationic DiOC2(3) and anionic SqSC4 probes have been used for image analysis and transmenbrane potential (Δψp) estimation in real-time studies. Fluorescence spectra resulting from the accumulati...