Endocrine Abstracts

Background and aim: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth, cardiometabolic disturbances and an increased neoplastic risk. This study aims to assess the tumorigenic potential of GH excessive secretion.Patients and Methods: We conducted a retrospective study (1997-2020) at the Endocrinology department of Hedi Chaker...

Background and aim: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and cardiometabolic disturbances. This study aims to describe the ophthalmologic complications seen in acromegaly.Patients and Methods : We conducted a retrospective study (1997-2020) at the Endocrinology department of Hedi Chaker University Hospital, Sfax,...

Background and aim: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and cardiometabolic disturbances. This study aims to determine the prevalence of obesity in patients with acromegalyPatients and Methods : We conducted a retrospective study (1997-2020) at the Endocrinology department of Hedi Chaker University Hospital, Sfa...

Objective: To describe the phenotypic and molecular characteristics of familial thyroid dyshormonogenesis (FTDH) in the Tunisian population.Patients and Methods: A retrospective descriptive study including two related (R and K) with high consanguinity whose members are carriers of FTDH. Biological and genetic screening was proposed for all consenting members.Results: FTDH was identified in 11 patients (8 girls, 3 boys) with a mean ...

Background and aim: Hyperthyroidism status can be complicated by polymorphic neuromuscular manifestations sometimes revealing. In the majority of cases, these disorders regress during the transition to euthyroidism. We report in this work 6 observations illustrating the neuromuscular manifestations seen in hyperthyroidism.Observations: We report two cases of chronic myopathy: a man and a woman aged 47 and 55 years respectively, hospitalized for hyperthyr...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder caused by mutations in the MEN1 tumor suppressor gene and is characterized clinically by tumors in two or more endocrine glands, such as the pituitary gland, parathyroid glands or pancreatic islets. We describe an atypical presentation of familial hyperparathyroidism evoking the diagnosis of MEN1 in the first place.Observations: We report a three-member family....

Intoduction: Pitiutary tumor is considered as the first etiology responsable of secondary hypopituitarism. Hypogonadotropic hypogonadism is the most commonly reported lesion.Meterials and methods: It is a retrospective study including 77 cases of prolactinoma. The data collection was done over 17 years, between 2000 and 2017.Results: Gonadotropic deficiency was confirmed in 48 patients (63.6%). A significant negative correlation wa...

Introduction: The non-functional pituitary adenoma (NFPA) is a benign tumor, which has a progressive development but it is a severe tumor by its neuro-ophthalmological and endocrine repercussions.Patients and methods: It is about a descriptive and retrospective study conducted in 35 patients collected in the endocrinology department of Sfax between January 2000 and December 2017. The diagnosis of NFPA was based on the presence of pituitary adenoma on hyp...

Introduction: The simultaneous occurrence in the same patient of more than one endocrinological condition is rare and was described in the multiple endocrine neoplasia (MEN). Here, we report a patient with an unusual combination of primary-hyperparathyroidism, papillary thyroid microcarcinoma, primary-hyperaldosteronism and ACTH-independent Cushing’s syndrome.Case description: A 54-year-old women with a primary-hyperparathyroidism was admitted to ou...

Introduction: Neuroendocrine tumors may develop in almost any organ. These types of tumors may present with giant and asymptomatic mass. We describe a case of a large non functional neuroendocrine tumor reported in the department of endocrinology and diabetology of Hedi Chaker hospital in Sfax-Tunisia in 2016.Presentation of case: A 28 years old male presented with asthenia, gastric heaviness and epigastric pain. Further computerized tomography, a large ...