Endocrine Abstracts

Background: Testosterone therapy (TTh) may produce various side effects, particularly erythrocytosis, with short-acting testosterone (T) injections presenting the greatest risk. Other causes are smoking and obesity. Erythrocytosis increases blood viscosity, which may lead to thromboembolic complications. Aim: to study the frequency of erythrocytosis induced by TTh and its predictive factors on transgender males (TM) in the Gender Unit of our hospital.Met...

Introduction and objectives: The inhalation of tobacco smoke leads to an acute increase in cortisol, ACTH and GH concentration, both in chronic smokers as in non-smokers. However, most studies have failed to demonstrate differences between both groups in basal levels of these hormones in plasma or urine. Additionally, cholinergic pathways have been shown to play an inhibitory role in ACTH secretion in non-smokers. UFC and circulating levels of cortisol, ACTH and GH were evalua...

Introductions: Alterations of the somatotrophic and hypothalamic–pituitary–adrenal (HPA) axes occur frequently in patients with poorly controlled DM-1. These disorders could be related to abnormalities in the cholinergic tone regulating both hormonal axes.Subjects and Methods: UFC (urinary free cortisol) on 24 h urine samples and the effects of placebo and pyridostigmine on ACTH, cortisol, GH and glucose circulating levels were studied in 16 yo...

Introduction and Objectives: In patients with poorly controlled DM-1, the frequently observed alterations of somatotrophic axis seem to be related to abnormalities in the hypothalamic cholinergic tone regulating this axis. The effects of cholinergic stimulation on GH responses to GHRH were evaluated in patients with poorly controlled DM-1 and the relationship of these responses to metabolic control and kidney function tests.Subjects and Methods: Microalb...

Background: Acromegaly results from excess growth hormone (GH) secretion by a pituitary adenoma in 95% of the cases. Discordant acromegaly is defined by the elevation of GH with normal levels of insulin-like growth factor type 1 (IGF-1) or normal levels of GH associated with an elevation of IGF-1. Its an important situation in the follow-up period of patients with acromegaly because there is little information about patient treatment, comorbidities and follow-up. The objective...

Introduction: Radioiodine whole-body scintigraphy (WBS) has been widely used for detection of differentiated thyroid cancer (DTC), based on the marked storage of iodine in functioning thyroid tissue. However, radioiodine uptake is not specific for thyroid gland. Iodine accumulation in lactating breast has been demonstrated, but it is rare in nonlactating breast.Case report: A 74-year-old-woman who underwent near-total thyroidectomy in 1988 due to a multi...

Our objective was to estimate the distribution of Spanish diabetic patients attending to individualized glycaemic targets recommended by the ADA/EASD consensus with and without considering hypoglycaemia risk. We conducted a cross-sectional study in a Spanish primary care setting between 2011 and 2012. A total of 5382 type 2 diabetic subjects under antihyperglycaemic treatment for at least 3 months prior to inclusion completed a study visit in which clinical data including age,...

Introduction: Some metabolic diseases, including type 1 (T1DM) and type 2 (T2DM) diabetes mellitus have an influence on bone homeostasis. These facts are of great socio-medical impact, since currently the DM2 and osteoporosis are considered public health problems.Objectives: (1) Determine the relationship between markers of bone metabolism and insulin resistance in postmenopausal women with and without T2DM.(2) Compare the bone min...

Introduction: Primary hyperparathyroidism (PHPT) is emerging as a cause of secondary hypertension. Between 20 and 50% of patients with PHPT have hypertension, this being directly proportional to the calcemia. The elevation of blood pressure in PHPT is mediated by hypercalcemia that acts directly stimulating the contraction of muscle fibers of the arterial vessel wall, and increases plasma renin levels and the release of catecholamines.Objectives: (1) Det...

Introduction: Patients with resistance to thyroid hormone (RTH) have variable tissue hyporesponsiveness to thyroid hormone (TH) due to a defect in the TH receptor (TR) β gene. So far, 124 different mutations have been identified among 343 unrelated families. Despite the TH resistance, some patients have symptoms and signs of hyperthyroidism and may have goiter. RTH is characterised by high TH and normal or high TSH concentrations. Differential diagnosis includes a TSH-pro...