Endocrine Abstracts

Insulin resistance and type II diabetes (T2D) are associated with activation of the Renin-Angiotensin-Aldosterone-System (RAAS) in part via regulation of its principal effector molecule, Angiotensin II (AngII). Endothelial cell activation leads to, among other factors, increased extracellular protein disulfide isomerase (PDI), a multifunctional protein that is critical to thrombus formation and regulation of reactive oxygen species. However, the effects of RAAS on PDI are unkn...

Background: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fractures. Anti-diabetic oral agents and insulin may also impact on fracture risk. There is however scarce data available on the effect of such therapies combined as usually prescribed in real-life practice conditions.Objectives: The objective of this study was to compare the risk of fracture among T2DM patients who are users of different antidiabetic treatments...

A growing number of studies suggest that extracellular fragments derived from plasma membrane receptors can play relevant functional roles in the development and progression of certain tumoral pathologies which might, therefore, serve as novel tools in the diagnostic and prognostic of such pathologies. In this scenario, the truncated somatostatin receptor sst5TMD4, which is overexpressed in various endocrine-related cancers (i.e. breast, prostate, neuroendocrine, liver and pit...

Response to therapy re-stratification approach has been recently included in the 2015 ATA guidelines as a risk-adapted approach to management of thyroid cancer. Our aim was to investigate the clinical utility of response to therapy variables obtained during early follow-up in combination with BRAF, a prominent oncogene in thyroid cancer with prognostic value. This was a retrospective multicenter study of 871 patients at 11 centers in Spain with papillary thyroid cancer followe...

Clinical Case: A hypertensive 60-year-old woman with nephroangiosclerotic stage IV chronic renal failure (eGFR 23.44 ml/min/1.73 m2) was referred to our hypertension clinic after the CT finding of a 26-mm left adrenal mass with adenoma density during hypertension workup, with normal right adrenal. Physical exam was unremarkable except for BP 167/98 mmHg. Plasma aldosterone was 353 ng/ml, PRA 1.3 ng/ml/h, ratio 90.2, K+3.1 mEq/l, and metanephrines were nor...

Introduction: Denosumab is a monoclonal antibody indicated in the treatment of postmenopausal osteoporosis. Hypocalcemia is a rare adverse effect.Case report: We present the case of a 58-year-old woman with a clinical history of bariatric surgery in 2001 and osteoporosis with multiple vertebral and hip fractures. Under treatment with Zinc sulphate, Vitamin A, 25-OH-vitamin D, calcium and iron. She came to the A&E for general malaise, generalized weak...

A 49-year-old male was referred to our Hypertension Clinic with uncontrolled hypertension, treatment Valsartan/Amlodipine/Hydrochlorothiazide 80/10/25 mg + Doxazosine 4 mg. Mean home BP was 156/103 mmHg. Personal history: dyslipidaemia, central obesity and type 2 diabetes, with mild diabetic retinopathy, persistent microalbuminuria and preserved renal function. Treatment: Metformin/Sitagliptin 1000/50 mg BID; Pravastatin/Fenofibrate 40/160 mg. Height 172 cm, weight 112 kg, BMI...

Metabolic syndrome (MetS) and type-2 diabetes (T2D) development is critically affected by the loss of phenotypic flexibility (i.e. the difficulty to cope with stressors to maintain metabolic homeostasis). Thus, it is essential to identify key modifiers of phenotypic plasticity that define individual susceptibility to develop T2D. Particularly, there is emerging evidence that alternative mRNA splicing is dysregulated under adverse metabolic-conditions, such as T2D, in several t...

Introduction: TSHomas are rare TSH producing tumors, whereas chronic autoimmune thyroiditis is a frequent condition. Patients with TSHoma are characterized by increased circulating levels of peripheral thyroid hormones, but when a chronic autoimmune thyroiditis is associated, they may be normal or low, making the diagnosis challenging.Case report: A 55 year-old woman, with previous medical history of obesity and impaired fasting glucose, was diagnosed of...

Introduction: Euvolemic hyponatremia (HN) caused by the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) can predate a diagnosis of malignancy. It is thus essential to accurately diagnose the etiology of HN/SIADH when detected.Methods: Retrospective, descriptive study of all 52 oncological/hematological malignancy patients diagnosed with SIADH in our Department between January 2011 and December 2016. HN was detected via computerized Prima...