Endocrine Abstracts

Introduction: This study aimed to investigate possible direct and indirect association of socio-demographic and lifestyle factors with central obesity and overweight status in the Tehran Lipid and Glucose Study (TLGS) population.Methods: After excluding under- and over-reporters, a sample of 2747 TLGS participants (58.3% female) aged≥20 years were recruited in the study. Overweight and central obesity were defined as having BMI ≥25 kg/m2...

Introduction and objective: Clinically nonfunctional pituitary adenomas are relatively an uncommon disease. The aim of this work is to describe the clinical characteristics and to review the results of transsphenoidal surgery (TS) of pituitary adenomas in a reference centre.Methods: A retrospective study (1995–2014) of 66 patients (50% men) diagnosed with pituitary adenomas by a magnetic resonance imaging (MRI) was conducted. demographic, clinical, ...

Introduction: Ogilvie’s syndrome (acute colonic pseudo-obstruction) is a syndrome in which the clinical features resemble those of mechanical obstruction with massive colonic dilatation, in the absence of any demonstrable evidence of such an obstruction in the intestine. The exact pathophysiology of intestinal pseudo-obstruction remains to be elucidated. Current theories continue to suggest the idea of an imbalance in the autonomic nervous system. The initial therapy rema...

Introduction: Graves’ orbitopathy is usually associated with Graves’ Disease, which is typically characterized by hyperthyroidism and goiter. However, in rare situations, Graves’ disease can also present with hypothyroidism and orbitopathy.Case report: Male, 38 years old, followed by his ophthalmologist for thyroid orbitopathy (exophthalmos right>left and conjunctival hyperaemia since 1 year ago) associated with asthenia, tiredness and...

Only two human cell lines are available for adrenocortical carcinoma (ACC) which do not reflect the functional heterogeneity of individual patient tumors and metastases. To overcome the lack of preclinical models for testing of novel therapeutic options in recent years we aimed at the development of patient-individual tumor models for endocrine tumors. Therefore, pieces of surgically excised patient tumors were implanted subcutaneously in the neck of athymic nude mice. To inve...

In the last years estrogens have emerged as important regulators in male reproductive function. Spermatogenesis depends on the tight control of germ cell apoptosis and several studies indicated estrogens as playing a role in this process. The stem cell factor (SCF), a membrane-bound cytokine, and its receptor (c-kit), and the Fas ligand (FasL)/Fas receptor (FasR) system are powerful mechanisms controlling germ cell proliferation and apoptosis through the direct membrane commun...

Background: Male adolescents with hypogonadotropic hypogonadism (HH) or delayed puberty start pubertal induction from 12–14 years. Testosterone obtains secondarysexual characteristics and improves psychosocial well being. Gonadotropin releasing hormone (GnRH) or recombinant FSH (rFSH) and human chorionic gonadotropin (hCG) generate testicular growth (fertility) and testicular testosterone production. HCG-rFSH treatment increase testis size and improves the quality of life...

Introduction: The composite pheochromocytoma is a rare adrenal medullatumour that combines a pheochromocytome and a neuroblastic tumour. We present the case of a composite phenochromocytoma discovered in a patient with neurofibromatosis type 1.Case report: Patient aged 64 years referred to our department by his dermatologist for the exploration of a left adrenal mass discovered during the practice of a CT scan and then an 18F-FDG MRImade as part of an ex...

We report the case of a 28-year-old Emirati lady with type 1 diabetes (weight 51 kg, BMI 20.82 kg/m2) diagnosed at 3 years of age who presented to our centre with problems at her insulin injection sites. She had poor glycaemic control and her diabetes was complicated by retinopathy; other past medical history included vitamin D deficiency. All her seven siblings had diabetes and were on insulin; both parents had type 2 diabetes.In 2017, she wa...

Introduction: Langerhans Cell Histiocytosis (HCL) is a rare granulomatous disease, unknown etiology, with a wide clinical spectrum. The pituitary is affected in 25% of cases, with diabetes insipidus being the earliest and most frequent feature. Although it is more common in pediatric age, it can also be developed by adults.Clinical case: A 39-year-old, caucasian, woman presents with polydipsia with 5L/day of water and an appetite for cold drinks, polyuri...