Endocrine Abstracts

Introduction: Data on the role of endogenous sex steroids in cerebrovascular disease is sparse. Our aim was to investigate the clinical relevance of circulating sex steroids in a postmenopausal acute stroke population and search for associations with disease severity and short-term outcome.Patients and methods: We prospectively studied 302 postmenopausal female patients hospitalized for an acute stroke in two tertiary hospitals, during a time period of 2...

Introduction: Several studies have examined the association of the common PvuII polymorphism of the estrogen receptor alpha (ERα) gene with the risk of stroke. Data linking the polymorphism with the severity and outcome of cerebrovascular disease is lacking. We looked for possible associations of the PvuII polymorphism with stroke severity and short-term prognosis in a cohort of female stroke patients.Patients-Methods: We studied 302 postmenopausal ...

Introduction: DHEAS is among the most abundant sex steroid products of the adrenal gland. DHEAS levels have been repeatedly associated with cardiovascular disease, but data concerning cerebrovascular disease, especially in women, is lacking. In this study, we aimed to investigate the role of DHEAS in a female population suffering an acute stroke.Patients and methods: We studied 302 consecutive female patients presenting with an acute stroke hospitalized ...

Introduction: Autoimmune disease (AD) is more common in women than in men. Sex hormones may play a role. Sex hormone receptors (SHR) are expressed in cells of the autoimmune system. We investigated the possible role of hormonal parameters and of common gene polymorphisms of the estrogen receptor alpha (ESR1), beta (ESR2) and androgen receptor (AR) in the presence of AD in men.Methods: In total 227 men were studied; 125 had at least o...

Objectives: Glucocorticoids may affect cardiovascular risk. Polymorphisms in the glucocorticoid receptor (GlucR) gene have been associated with increased risk for cardiovascular disease. We investigated whether the common Bcl1 polymorphism of the GlucR gene (associated with increased sensitivity to glucocorticoids) may be associated with early markers of atherosclerosis.Methods: Two hundred and fourteen middle aged apparently healthy subjects (age &#8230...

Introduction: The relation between vitamin D deficiency and gestational diabetes mellitus (GDM) has been rarely addressed in the literature with conflicting results. The aim is to determine the association between maternal serum 25(OH)D and glucose metabolism in Caucasian pregnant women.Patients and methods: In a prospective study 157 pregnant women aged 31.2±5.8 years underwent a 100 g OGTT in the third trimester of pregnancy, during which serum 25...

A common polymorphism of the ERβ gene (AluI) located in 3′-UTR of exon 8 has been shown to be associated with clinical features of altered estrogen action in tissues where this gene is expressed. It has recently been shown that GnRH neurons express ERβ, indicating that this receptor may participate in the feedback regulation of gonadotrophin secretion. We therefore studied the association of gonadotrophin levels and the AluI polymorp...

Background: TSH levels within the normal range have been associated with increased blood pressure (BP). TSH itself might be involved, especially as extrathyroidal actions of TSH exist.We investigated whether elevated TSH levels after acute rhTSH administration may result in alterations in BP in euthyroid individuals.Methods: Twenty-six euthyroid female subjects thyroidectomised and on T4 suppressive dose, were evaluated ...

Background: Swyer syndrome is a type of pure gonadal dysgenesis 46 XY caryotype in phenotypically female patients. A rare case of Swyer syndrome complicated by dysgerminoma and Retiform Sertoli-Leydig cell’s tumor is reported.Case presentation: A 20-year-old phenotypically female patient presented to our department with primary amenorrhea. She was 1.68 m and weighed 82 kg (BMI 28). She presented with minimal breast development, sparse axillary and p...

Introduction-aim: It has been suggested that estrogen may play an important role in the regulation of endothelium-dependent vasodilatation in both sexes. Especially in men, estradiol administration has been shown to improve endothelial function; however such reports are conflicting. The aim of our study was to examine the relation of endogenous sex hormone levels with markers of early atherosclerosis in a cohort of apparently healthy individuals.Methods:...