Endocrine Abstracts

Objective: Simultaneous occurrence of MTC and DTC is frequently found. It is unclear whether there is a common pathogenic mechanism. Aim of our study was to characterize clinical features of MTC when coexisting with DTC.Methods: Of 273 MTC patients followed-up in our department 39 (14.3%) had MTC simultaneously with DTC. They were divided in 4 subgroups according to size. Clinical histopathological data were recorded.Results: The p...

Introduction: Mutations in the ret gene are responsible for the transmission of inherited medullary thyroid cancer (MTC). In recent years a high prevalence of the ‘rare’ exon 8 mutation (G533C) has been found in patients with inherited MTC in Greece. The aim of this study was to record with more detail the place of origin of these families in the country.Design: We analysed the details of 44 patients belonging to 22 families who were c...

Objectives: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic ones (sMTC). We examined the presentation of these entities in our centre.Methods: 223 MTC patients (familial: 42.6%, males: 36.8%) were followed for 0.9–30 years (mean 6.23±5.9, median 4.0 years). 44 (19.7%) fMTC patients were operated after genetic screening.Results: Median age at diagnosi...

Introduction: In recent years, micro papillary thyroid carcinomas (mPTCs; ≤1.0 cm) are increasingly diagnosed. Although clinical course is usually favourable, disease persistence may occur and multiple treatments needed. We examined factors that could be predictors of clinical behaviour and disease persistence.Patients and methods: 478 mPTC patients (78.9% females) followed-up for 0.6–10 years were classified according to tumour size in group ...

Objectives: Patients with thyroid dysfunction due to AITD have been found to have increased oxidative stress. Possible associations of oxidative stress with thyroid hormone (TH) and thyroid autoantibodies (ThAb) levels in euthyroid patients with autoimmune thyroiditis have not been adequately studied. We examined possible associations of oxidative stress markers with TH levels and with the presence of ThAb in euthyroid women with Hashimoto’s thyroiditis (with or without T...

Objectives: In familial MTC there is genotype-phenotype correlation. The phenotype and clinical outcome in exon8 (G533C) carriers has not been well established.Methods: 95 patients operated for familial MTC (27.2% males) were followed for 0.9–30 years (mean 8.0, median 5.5 years). 45.3% (n=43) were exon8 carriers (exon8MTC) and the remaning were non-exon8MTCs (n=52, exons 10, 11, 13, 14, and 16). Pre-, postoperative calcitonin, ext...

Introduction: Differentiated thyroid carcinoma (DTC) has generally a good prognosis and is associated with prolonged survival. A minority of patients may have persistent disease and rarely aggravation during f/u. We investigated factors which may influence the persistence of disease in patients who had undergone ablation with I131.Patients and methods: 903 DTC patients were referred in our center from 1968 to 2012. Five hundred and forty-one (...

Introduction: Recently, small medullary thyroid carcinomas (sMTCs) (≤1.5 cm) are frequently diagnosed, occasionally as incidental findings in surgical and autopsy specimens. Their clinical course varies. We examined whether tumor size is a predictor of clinical behavior.Patients and methods: One hundred and one sMTC patients (36.6% males, 47.1% familial) followed-up for 0.9–35 years. Patients were classified according to tumor size (cm) in gro...

Introduction: In the literature there are only three papers so far, addressing the impact of thyroid antibodies (Anti-TPO) on pregnancy in Type1 Diabetic Women (DM1) and these present conflicting results. The aim of the study is to evaluate the presence of Anti-TPO in DM1 pregnant women and whether these are related with differences in thyroid function, metabolic control and pregnancy outcome.Methods: In 78 DM1 women with singleton pregnancies Anti-TPO, ...

Introduction: GDM seasonability has been rarely addressed, with conflicting results. The aim of the study is to evaluate monthly GDM incidence in a large group of Greek women.Methods: 7618 pregnant women underwent 100g OGTT during the third trimester (GDM: ADA 2000 criteria). Seasonal, monthly GDM incidences and mean seasonal glucose levels during OGTT were calculated. Mean month temperature data were obtained from the Greek Meteorological Service.<p...