Endocrine Abstracts

Introduction and aims: Triggering receptor expressed on myeloid cells 1 (TREM-1) is secreted by macrophage and neutrophils in adipose tissue to released pro-inflammatory chemokines and cytokines. TREM-1 activate Janus kinase 2 (JAK2), protein kinase B (PKB/AKT) and extracellular signal related kinase (ERK1/2) pathways and upregulate the expression of genes involved in the inflammatory response. We aimed to indicate associations with serum TREM-1 levels, total sulfhydryl (SH) a...

Introduction: Mucormycosis is a serious fungal infection, It is frequently observed in immunocompromised patients such as diabetes mellitus. The most common clinical presentation of mucormycosis is rhino-orbita- cerebral infection.Case presentation: A seventy three-years- old man with diabetes mellitus who was operated due to orbital trauma a mounth ago. Periorbital cellulitis and diabetic ketosis developed during post-operative period and the patient wa...

Background: Endogenous Cushing’s syndrome (CS) is associated with increased susceptibility to infections and mortality. Previously reported effects of hypercortisolism on immune function include a reduced CD4+/CD8+ ratio with a shift towards IL4+T helper cells (Th2), suppressed NK-cell cytotoxic activity as well as a low-grade inflammatory profile.Aim: This cross-sectional single center study aims to compare immune phenotype in patients with overt C...

Calcification is a physiological process in bone but occurs also pathologically in the vasculature, favouring cardio- and cerebrovascular diseases (CVD). Vitamin K metabolites, particularly K1 and MK-4, are associated with decreased vascular calcification especially in patients with chronic kidney disease. We investigated the expression of components of the vitamin K cycle (VKC) and the MK-4 synthesis (MKS) in aorta and bone of 26 brain dead organ donors in order to identify d...

Introduction: Vitamin D (VD) is metabolized locally in the testis, and ablation of the VD receptor (Vdr−/−) in mice has proven a valid model for hereditary VD resistant rickets. However, only one of three published Vdr−/− strains presented with male infertility. Here, we investigated reproductive hormones, gene expression and the testicular histological phenotype of male Vdr−/−mice,...

Calcification is physiologically present in bone but also pathophysiologically in the vasculature, favouring cardiovascular diseases. Our aim was to investigate changes in the expression of calcification regulators (CR) during vascular calcification in bone and vasculature. Gene expression levels of OPG, RANKL, OPN, MGP, BSP-II and RUNX2 were determined in bone, aorta and arteria ilica externa tissue samples of 22 transplant donors. Gene expression levels during atheroscleroti...

Aim: 402 patients who were admitted and FNA was done in the Endocrinology Clinic at EBEAH were enrolled in this study. 340 (85%) of them were females and 62 (15%) of them were males. The age range was between 16 and 82. There weren’t any statistical differences in age between both sexes. Thyroid cancer is reported to constitute <2% of cancers in humans. At the same time, it is the most lethal endocrine malignancy. In the literature it is stated that 3% of all cancers ...

The pathologist cannot easily decide some thyroid fine-needle aspiration biopsy (FNA) into the benign, suspicious, or malignity and this condition are reported as ‘atypia of undetermined significance’ (AUS) or ‘follicular lesion of undetermined significance’ in the Bethesda system. Diagnosis of AUS of a thyroid nodule is leaved an endocrinologist as well as the patients in a difficult situation. However, the risk of malignancy at AUS is ~5–15%. Our aim...

Introduction and aim: Bethesda system for thyroid cytopathology has been widely used recently. Approximately 3–7% of thyroid fine-needle aspiration (FNA) biopsy is considered as malign. Suspicious or malign nodules should likely to be resected. Aim of this study is to confirm the diagnosis of malign or suspicious for malignity according to Bethesda classification in patients with nodular goitre after thyroidectomy.Materials and methods: Results of F...

Introduction and aim: Interpretation of follicular neoplasia classification according to Bethesda system in thyroid fine needle aspiration biopsy is very different among pathologist. A number of definition including ‘follicular lesion’, ‘follicular proliferation’, ‘follicular lesion of undetermined significance’, and ‘follicular neoplasia’ were used in terminology. A clearly discrimination between nodular goitre, follicular adenoma, and ...