Endocrine Abstracts

Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food int...

Introduction: Tyrosine kinase inhibitors (TKIs) are used for treatment of iodine-refractory differentiated thyroid cancer (DTC) in patients with progressive advanced disease.Sorafenib and lenvatinib are the TKIs currently approved for this indication.Objective: To describe the clinical experience in patients with iodine-refractory DTC treated with TKIs in our Institution.Materials and methods: Restrospective cohort study of patient...

Introduction: Poems Syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes, among other features. Literature describes endocrine abnormalities at least in 93% of patients with Poems Syndrome during the diagnosis as well as during the follow-up. The most common deficiencies ranked by their frequency are hypogonadism, hyperprolactinemia, hypothyroidism, abnormal glucose meta...

Introduction: Grave’s disease (GD) is an autoimmune disease characterized by the development of thyroid-stimulating hormone (TSH) receptor antibodies that have a stimulating effect on the thyroid gland. There is a rare but non-incidental and well-documented association between GD and thymic hyperplasia (TH). Nonetheless, this association is often underdiagnosed in routine clinical practice and the mechanisms behind this association have yet to be thoroughly elucidated. Th...

Retrospective study of patients with metastatic/progressive pheochromocytoma (PCC) and paraganglioma (PGL) treated with (131) I MIBG in our hospital during 2015–2018 period.Methods: There are no established criteria for establishing PCC/PGL as malignant apart from de presence of metastases at diagnosis. Radionuclide therapy (131) I-metaiodobenzylguanidine (MIBG) is frequently used in this patients when surgery is not possible. Indication of MIBG tre...

The effect of subclinical hypothyroidism (SH) and thyroid autoimmunity on adverse pregnancy and neonatal outcome, are still subject of interest and controversy. Nowadays, guidelines recommend establishing reference values of local thyroid hormones that allow definition of the SH in a specific population. The objective of this study was to assess the effect of SH and autoimmunity in early pregnancy on adverse pregnancy and neonatal outcome in our population. The reference range...

Gestational diabetes mellitus (GDM) is associated with an increased risk of pregnancy-induced hypertension (PIH). Ambulatory blood pressure monitoring (ABPM) has been used to screen for PIH and preeclampsia in normotensive type 1 diabetic women. To date, there are no data regarding ABPM in women with GDM. The aim of the study was to establish blood pressure (BP) profiles for pregnant with GDM, using ABPM and determine whether a BP pattern can define a population at risk for de...

Methods: Retrospective and descriptive study in a sample of 36 patients with suspected hypoglycemia who were admitted to our Service to perform a 72-hour fasting test. Demographic, clinical data and results of fasting test were analyzed. Endogenous hyperinsulinism criteria were considered to be the combination of plasma glucose <55 mg dl, insulin >3 mcrU / ml and C peptide > 0.6 ng/ml, in the absence of detection of sulfonylureas.Results: The...

Background: Despite a high relapse rate, antithyroid drugs (ATDs) remain the first-line therapy of Graves’ disease (GD). Long-term follow-up studies of GD in Spain are scarce. Our aims were to identify clinical differences between patients who relapsed vs those who attained remission and to describe the relapse rate of GD after ATD withdrawal.Methods: We analyzed patients with the first episode of GD who were treated with ATDs during 2010 - 2020, in...

Background: Sarcopenic obesity(SO) is an entity characterized by excess fat mass(FM) and low muscle mass (LMM) and function. Excess FM itself can lead to loss of muscle mass and function at any age. The combination of obesity and sarcopenia is a proven risk factor for frailty, comorbidities and mortality. New diagnostic criteria have been developed for this entity.Aims: To assess the prevalence and severity of SO with different indices by DXA, in a group...