Endocrine Abstracts

Background and aims: The hypothyroidism may be prior to the conception, hence the interest of studying women during the genital activity period. Our objective was to determine the prevalence and the etiologies of the hypothyroidism in childbearing age women.Materials and methods: Prospective study, on 270 childbearing age women. Study protocol: clinical examination, urinary iodine, thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid antib...

Introduction: Computed tomography (CT) scan is the first imaging method used to characterize adrenal lesions in order to select patients for surgical treatment. Our aim was to specify the performance of this tool in the work up of adrenal masses (AM) recruited in a department of Endocrinology.Material and methods: This retrospective study included 100 patients hospitalized in our department between 2008 and 2014 for adrenal tumors. After a systematic exc...

Introduction: Hyponatremia’s etiological diagnosis remains a challenge in the real life. Our aim was to report a patient who was sent for severe behavioral disorders revealing hyponatremia due to an isolated deficit in aldosterone. This observation emphasizes the extreme rarity of the disease which deserves to be reported.Case report: A young patient aged 34 with a history of autoimmune thyroiditis consulted for an acute and severe psychiatric syndr...

46, XY disorders of sex development are rare diseases secondary to gonadal dysgenesis (GD) and disorders of androgens synthesis or action. Familial forms of GD are very rare; we report here the observations of two siblings with 46, XY GD.The first patient whose parents were relatives, raised as a girl consulted at 3 years for ambiguous genitalia, at clinical exam we found a small phallus, partial fusion of labio-scrotal folds with one orifice at the phal...

Introduction: Iodine deficiency has serious consequences for both the mother and the offspring, it is a real public health problem. Our aim was to study the iodine status impact on thyroid parameters during the first trimester of pregnancy in women free of any current or previous thyroid disease.Patients and methods: Prospective study, on 145 pregnant women (mean age of 29.4±0.5 years) at 10.4±0.2 weeks of gestation. Women with disrupted thyroi...

Introduction: Hypothyroidism is known for its adverse effects for both the pregnant woman and her offspring. Our aim is to highlight the benefits of screening for hypothyroidism in all pregnant women with and without risk factors.Patients and methods: Prospective study, on 270 pregnant women. Women with disrupted thyroid balance, who smoke (active smoking confessed) and those followed for thyroid disease or taking medications that interfere with the thyr...

Introduction: Adrenal metastases used to be rare in endocrinology compared to others adrenal tumours, and deemed to have a dire prognosis. Our aim is to analyze 13 cases in order to study their morphological aspects, their causes, and their outcome.Subjects and method: Thirteen cases were studied over a long period of time (2000–2012). All of them had biological, hormonal, and radiological assessments.Results: We had ten men a...

Introduction: Congenital trans-sphenoidal meningocele (TM) is a rare clinical entity. It can be traumatic, congenital or from tumour origin. It results from a defect in the sphenoid bone ontogenesis. In its classical form, the TM is revealed in adults, frequently in women in the fourth or fifth decade by rhinorrhea or cerebrospinal fluid leak through a bony defect in the sphenoid floor. Our aim is to report a case of large TM without rhinorrhea, and as a part of midline abnorm...

Several observations brought reported a big frequency (12–50%) of pituitary insufficiency and abnormalities of the median line. The endocrine disorders are hypothamic origin and come along of pituitary ontogeny in more 30% of the cases. These abnormalities are associated with a defect of the embryological development of the bird nasofrontal which allows the development of various regions of the encephalon and the face. We report the observations of two boys KY 18 years ol...

Introduction: Compared to secondary amenorrhea, primary amenorrhea is deemed to be a rare condition. Our aim is to study its annual frequency during a long period of time, and to analyze its different aetiologies in an Endocrine Department.Methods: All patients referred for primary amenorrhea between 1980 and 2012 were studied. We took in account personal and family history, clinical examination, hormonal, cytogenetic and immunological assessments, and r...