Endocrine Abstracts

Introduction: In medical practice ambiguous genitalia is a relatively are condition. The combination of two causes in genital malformation is exceptional. Our aim is to describe a person having an abnormal karyotype with a chimerism (46,XY/46,XX) and a deficit in 17β-hydroxysteroid dehydrogenase 3 (17β-HSD): an enzyme in the testes that transforms D4 Androstenedione to testosterone and androstenedione to dihydro testosterone or DHT.Case report:...

Introduction: Generously supported by IPSEN)-->Epilepsy is a heterogeneous condition with different aetiologies including genetics, cerebral trauma, toxic exposures, infection, vascular diseases and neoplasms. Among the last ones, pituitary tumours (PT) are rarely responsible of convulsions, except when they are very large invading the nervous system. Our aim is to analyze the conditions under which the epilepsy appears and disappear...

Introduction: Metastases of thyroid carcinoma to the choroid and/or orbit are rare and usually occur at an advanced stage of the disease. The principal symptoms are decreased or blurred vision and/or persistent eye pain but they can be totally asymptomatic. They are diagnosed by ultrasound ocular CT and/or MRI scanning. The diagnosis is certain if they fix radioactive iodine. Their prognosis is very bad. Enucleation is the treatment of choice in cases of visual impairment. We ...

Introduction: Glucose metabolism disorder (GMD) is a classic complication of acromegaly, but its frequency varies from study to study.Aim: We aimed to analyze GMD frequency in our population, and predictive factors such as: family history of diabetes mellitus (DM), age, gender, and GH rates.Subjects and methods: It is a prospective study where 75 hypersomatotropic subjects were analyzed. They all had fasting and postprandial blood ...

Although GH has been implicated in the pathogenesis of retinopathy in diabetic subjects, the frequency of retinopathy in diabetic acromegalic subjects is deemed to be rare. The aim of our study is to evaluate the prevalence of retinopathy in hypersomatotropic patients.Subjects and methods: In total, 40 acromegalic diabetic patients (21 M, 19 F, mean age=50 years) underwent funduscopy to search for diabetic retinopathyResults: Among...

IGF1 represent an important key player in several physiologic process, so it can be implicated in different pathologies among delays of growth. A comparative study was realized comparing a group of healthy Algerian children of normal size (n: 266) and a group presenting a GH deficiency (GHD n: 107)to a group of healthy westerners children of normal size(Serie of ROSENFIELD).The results are as follows: Before the age of 04 years, there is a ...

Introduction: Charles Bonnet syndrome is almost unknown by the endocrinologists. It is composed by visual hallucinations that do not react with the patient contrary to psychiatric hallucinations. The abnormal visions (generally hidden by patients) appear in subjects with an impaired vision of one of both eyes as in the following case:Case report: A man aged 27, was referred for acromegaly secondary to a huge invasive somatolactotrope pituitary adenomas d...

Clinical presentation of pituitary adenomas is influenced by age of patients and stage of the tumour at diagnosis. In this study we intended to analyse the features of pituitary adenomas in old patients.Subjects and methods: It is a retro- and prospective study concerning 37 patients (19F/18M) aged 60 years and over harbouring a pituitary adenoma, these patients were divided into two groups:Group 1 (G1): Patients with invasive and/or giant tum...

Introduction: Glucose metabolism disorder (GMD) is a classic complication of acromegaly, but its frequency varies from study to study.Aim: We aimed to analyze GMD frequency in our population, and predictive factors such as: family history of diabetes mellitus (DM), age, gender, and growth hormone (GH) rates.Subjects and methods: It is a prospective study where 75 hypersomatotropic subjects were analyzed. They all had fasting and po...

Male prolactinomas are rare and considered as bad responders to medical treatment compared to female cases. Our aim was to evaluate response of pituitary macrolesions secreting prolactin (PRL) to dopamine agonists. Our population was composed of 34 men (mean age =36.6 years) with a diagnosis of macroprolactinomas: mean tumor size =35.5 mm (12 – 118) and mean PRL =2505 ng/ml (132 – 19996). Bromocriptine was used with a mean dose of 22.94 mg/day (3.75 – 80) and a ...