Endocrine Abstracts

Klinefelter’s syndrome (KS) is the most frequent form of sex chromosome aneuploidy. The classic form of KS is associated with a 47,XXY karyotype. Mosaic forms of KS are thought to occur in approximately 10% mainly in the form of 46,XX/47,XXY. Other forms of mosaicism are rare among which the 46,XX/47,XXY form is very rare and can manifest as an ambiguous genitalia at birth as reported in our case.A full term child presented at birth an hypospadias w...

Insulinoma is the most common cause of hypoglycemia related to endogenous hyperinsulinism in adults. It is very rare in pregnancy, fewer than 30 cases of insulinoma presenting in pregnancy have been reported so far and it’s managment is very challenging. We raported here the case of a pregnant women aged 35 years presenting an insulinoma.The diagnosis was made 1 year ago in the presence of hypoglycemia, high levels of inulin and C-peptide and a 10 m...

Introduction: Abnormalities of midline (AML) can be isolated or to be associated to secretory pituitary abnormalities that reflect a developmental defect of the hypothalamic pituitary (HP) region.Aim: Find AML in GH deficiency (GHD) and see their relationship with the appearance of the HP region and the severity of hypopituitarism (I P).Population and methodology: 160 children (141 ♂, ♀ 19) (IGH) underwent a clinical ex...

Lymphoma adrenal is a rare cause of adrenal tumor (0.5%). Bilateral primary lymphoma adrenal phenotype T is exceptional. We report two observations. MO 56 years old was hospitalized FOR exploration and therapeutic management of two large adrenal masses discovered on CT imaging after back pain, and weight loss. Physical examination revealed a patient asthenic, with no signs of hypersecretion. The rest of the examination was unremarkable and research call signs primary neoplasm ...

Introduction: Suppurative meningitis (SM) is a life threatening disease. It is rarely observed as a primary presentation in large pituitary tumours (PT) destroying the sellar floor and/or invading the skull base. Our aim is to report 3 SM revealing macroprolactinomas.Case No. 1: A man aged 22, consulted for vomiting and fever. The diagnosis of SM was confirmed by lumbar puncture and blood cultures. Cerebral MRI showed multidirectional PT invading caverno...

Introduction: The occurrence of primary pituitary tumour and cerebral schwannoma in the same person is very rare. Only few cases have been reported so far. The mechanism of this association is still unclear.Aim: Our aim is to report a man with two different brain tumours: a prolactinoma and a cerebellopontine schwannoma in order to discuss the possible mechanism of multiple neoplasms arising in the same person.Case report: A man ag...

Introduction: Acromegaly is a relatively rare disease with numerous complications. Our aim is to look for visceral abnormalities and tumour development in subjects with GH and insuIin like GH (or IGF1) excess.Subjets and methods: It is a retro-and prospective study that takes in account 112 patients at diagnosis, with pur pituitary tumours secreting GH, or mixed tumours secreting prolactin and GH diagnosed between 1980 and 2012. They all were questioned ...

Introduction: Generously supported by IPSEN)-->Pituitary tumours are known to cause headaches and visual troubles by compressing pituitary adjacent structures. Pressure on more distant structures is exceptional. In very large tumours such as prolactinomas, mixed adenomas or craniopharyngiomas, hydrocephalus, convulsions, memory troubles and even unconsciousness can be observed, but to our best knowledge motor deficits, such as hemipl...

Introduction: Adrenal metastases due to thyroid cancers deemed to very rare as adrenal glands are not a common site of metastases from thyroid cancer. When the phenomenon occurs the prognosis is very poor as adrenal metastases usually do not fix radioactive iodine. Our aim is to report three cases.Case reports: No. 1: a woman aged 57 harbouring anaplastic thyroid cancer classified T4, N1, M0, consulted for back pain, severe fatigue and skin pigmentation....

Introduction: Prolactinomas are more invasive in males. Giant ones (height ≥4 cm) are relatively rare in literature.Our aim is to analyze their frequency, their radiological aspects, and their neurological, endocrine and ophthalmological complications.Methods: All of them had clinical exam, hormonal, ophthalmological, and radiological assessment based on cerebral MRI. Mixed adenomas were excluded. Positive diagnosis was based...