Endocrine Abstracts

Objectivs: Plasma NT-proBNP is inversely associated with BMI in patients with heart failure (HF). A possible mechanism may be the lipolytic effect of natriuretic peptides on abdominal fat.Myostatin is previously described as a negative regulator of skeletal muscle mass in cachexia.We assessed the hypothesis that body composition is related to plasma NT-proBNP and that myostatin levels are associated with loss of fat free mass (FFM)...

Introduction: The neurohormones A and B-type natriuretic peptides are markedly increased in patients with heart disease, and are well established as useful diagnostic biomarkers. Obesity is a known risk factor for cardiovascular disease. Cross sectional data suggest however that plasma levels are reduced among obese. Therefore, the aim of the present study was to investigate the impact of weight loss and corresponding changes in body composition on plasma levels of A and B-typ...

Introduction: α-Defensins are recently described peptides, which are part of the innate immune system. Increased circulating levels are observed in conditions associated with chronic low grade inflammation, such as ischemic heart disease and in diabetes mellitus (DM). Recently we reported adverse prognostic implications of high α-defensins in patients with type 1 DM. However, it is not clear whether this finding may be generalized to include other groups such as pati...

Objectives: Measurement of TSH-receptor antibodies (TRAb) in hyperthyroid, pregnant women is an important tool when distinguishing between the autoimmune Graves’ disease and the physiological gestational hyperthyroidism. Evidence to support a cut-off for TRAb in early pregnancy is needed along with information on the frequency and follow-up of TRAb-positive as opposed to TRAb-negative hyperthyroidism.Methods: Within the North Denmark Region Pregnanc...

Objective: To evaluate the value of the thyrotropin-releasing hormone (TRH) test in the diagnosis of central hypothyroidism (CH) in patients with pituitary disease.Methods: Systematic evaluation of 368 TRH tests including measurements of TBG corrected thyroxine (T4corr), baseline TSH (TSH0) and fold and absolute TSH increase (TSHfold, TSHabsolute) in patients with pituitary disease.Result...

Background: Hypogonadism is prevalent during opioid treatment, but the effect of testosterone replacement treatment (TRT) on body composition, pain perception, and adrenal function is unclear.Purpose: To measure changes in body composition, pain perception, quality of life and adrenal function after TRT or placebo in opioid treated men with chronic non-malignant pain.Methods: Double-blinded, placebo-controlled study in 41 men (&#62...

Objective: Physiological alterations challenge the assessment of maternal thyroid function in pregnancy. It remains uncertain how the reference ranges vary by week of pregnancy, and how the classification of maternal thyroid disease vary by analytical method and type of thyroid function test.Method: Consecutively collectedserum samples from 6.282 pregnant women in the North Denmark Region, 2011–2013, were used for the measurement of thyrotropin (TS...

Background: Scintigrafically cold nodules are hypofunctioning areas in the thyroid gland. These nodules are common and as the risk of malignancy is low, surgery is only necessary in very few cases. Fine Needle Aspiration Cytology (FNAC) is the standard method for detecting malignant tumours. However, FNAC is a difficult diagnostic procedure which often gives insufficient working material.Materials and methods: A prospective study was designed to calculat...

Objective: The beneficial effects of testosterone treatment (TT) in men with low normal testosterone levels are debated. Chemokine levels have not previously been evaluated during TT in combination with strength training (ST).Design: A randomized, double-blinded, placebo-controlled study of 6 months TT (gel) in 54 men aged 60–78 years with bioavailable testosterone (BioT) <7.3 nmol/l and waist circumference >94 cm randomized to TT (50–1...

Objectives: Thyroid disease in women of reproductive age is predominantly of autoimmune origin, and thyroid peroxidase antibodies (TPO-Ab) as well as thyroglobulin antibodies (Tg-Ab) are key markers of autoimmune hypothyroidism. Adding to this, much focus in pregnancy is on euthyroid women who are positive for thyroid autoantibodies. The observational findings are diverse, and evidence to substantiate the applied cut-offs for definition of thyroid autoantibody-positivity in ea...