Endocrine Abstracts

Introduction: Insulinomas are pancreatic neuroendocrine tumors (PNET), characterized by insulin hypersecretion syndrome with the development of hypoglycemia. The incidence of the tumor is 3-10 cases per million inhabitants. The average age of onset is 40-50 years old, being more frequent in women. Case Reports: We present a clinical case of a patient with CREST syndrome and difficult-to-control hypoglycemia. Female patient, 81 years old, with a history o...

Background: Autonomic hyperfunctioning thyroid nodules account for approximately 5% to 10% of all thyroid nodules. Compared with non-toxic nodules, hot nodules are traditionally believed to have an exceptionally low malignancy rate, and this has led to recommendations not to perform fine-needle aspiration (FNA) on these lesions, regardless of their size. However, recent studies have questioned the presumed low risk of malignancy in hot nodules, suggesting that the incidence of...

Objective: Analyse possible effects on physical examination, blood count, liver and kidney function, and steroidogenic hormones synthesis. Know the satisfaction of patients with the first injectable treatment for hypercholesterolemia approved in our country.Material and methods: Data were collected from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors. Clinical, physical and analytical data were collected at baseline...

Introduction: Alterations in foetal growth lead to neonatal health risks and favour metabolic diseases during adult life. Therefore, the study of birth weight determination and its modifications is crucial for metabolic diseases prevention. Placental growth is a key factor in foetal growth. It has been suggested that insulin and the IGF system play an important role in foetal growth and placental development and function. Although, insulin and IGFs in the umbilical cord blood ...

Background and aim: Low T3 syndrome is associated with a poor prognosis in patients with chronic heart failure (CHF). It is controversial whether T3 treatment is indicated in CHF. A previous study using intravenous infusion of T3 for 72 h suggested a beneficial effect on cardiac performance.We aimed to evaluate the effect of 13 weeks of T3 treatment in patients with stable CHF on left ventricular ejection fraction (LVEF) compared to placebo.<p class=...

The 46 XX male syndrome (de la Chapelle syndrome or 46,XX testicular disorder of sex development -46,XX testicular DSD-) is a rare phenotype associated with disorder of the sex chromosomes. XX males exist in different clinical categories with ambiguous genitalia or partially to fully mature male genitalia, in combination with complete or incomplete masculinization.Clinical report: We describe the clinical, molecular, and cytogenetic findings of a 26-year...

Objective: One of the major problems related to the use of CSII, or intensive insulin regimens in general, is the calculation of accurate insulin boluses. Abolus calculator incorporated into the insulin pump, estimates the dose of insulin to be administered at the meal on the basis of the following parameters: current blood glucose, grams of carbohydrate in the meal, carbohydrate to-insulin ratio (CIR), insulin sensitivity factors (ISF), target blood glucose and quantity of in...

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

Objective: We retrospectively analyzed patients with type 1 diabetes onset, attended during the years 2005 and 2006 on the specific query of type 1 DM debut of a tertiary hospital, with initial treatment assessment, at 1 and 5 years evolution.Results: Patients were treated for newly diagnosed DM 1, 25 patients (72% male, 28% female) mean age 23.2 years (14–36), mean BMI: 23.18 (18–33.8%).The clinical presentation included: 88.24% presented with...

Objective: To evaluate the effects of GH on cardiac structure and function of patients with panhypopituitarism.Material and methods: We performed echocardiographic studies of patients with panhypopituitarism treated and not treated with GH at baseline and after 12 years of follow up. We collected clinical and echocardiographic data (systolic and diastolic ventricular diameter (LVEDD and DTSVI), interventricular septum thickness (IVS), left ventricular po...