Endocrine Abstracts

Objective: To characterize the age variations of fatness pattern in Spanish womenResearch methods and procedures:: A cross-sectional study of 2226 Spanish women (16 to 74 years old) women was undertaken to study age variations in adiposity, body composition, obesity and central fat distribution. The women were divided into seven groups: Group I (G I, 15–24 years), Group II (G II, 25–34 years), Group III (G III, 35–44 years), Group IV (G IV...

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

Introduction: Islet hyperplasia and nesidioblastosis are described in the non neoplastic pancreas of patients with gastrinoma. It is not definately established whether hypergastrinemia can influence these changes. Moreover, rarely insulinoma and gastrinoma occur in the same patient but cases of single tumours cosecreting both insulin and gastrin have been described. Otherwise, the syndrome of hyperinsulinemic hypoglycaemia with nesidioblastosis after Roux-en-Y gastric bypass h...

Congenital adrenal hyperplasia (CAH) is one of the most common autosomal recessive disorders. About 5–8% of cases are caused by the deficiency of steroid 11β-hydroxylase (CYP11B1) due to mutations in CYP11B1 gene. CYP11B1-inactivating mutations can be found without particular hot-spot spread over the entire gene. A good phenotype-genotype correlation exists for the patients suffering from 11β-hydroxylase deficiency (11OHD). The prediction of diseas...

Background: Acromegaly, a chronic disease caused by excess secretion of growth hormone (GH), has been known to reduce patients life expectancy. This increase in morbility and mortality is not only due to cardiovascular, respiratory or cerebrovascular disorders, but also to an increased risk for cancer.Subjects and methods: The aim of this study was to describe the associated malignant diseases among our fifty acromegalic patients. Clinical features of th...

Aim: To evaluate the response to growth hormone (GH) replacement in patients with growth hormone deficiency (GHD) after 1 year of treatment in terms of body composition, carbohydrate metabolism, lipid metabolism and quality of life.Method and patients: Twenty-eight patients with GHD with the following characteristics: 16 males, 10 with radiotherapy and 18 with panhypopituitarism, were included in our study. Body mass index (BMI) and waist hip ratio (WHR)...

Pendred syndrome is an autosomal recessive disorder with congenital-sensorineural deafness and goiter due to mutations in SLC26A4, that encodes a transmembrane protein, Pendrin. In thyrocytes, Pendrin is proposed to act at the apical pole to transport intracellular iodide into the follicular lumen.A Galician Pendred compound heterozygous patient was studied; a c.297delT in exon 3 and a new splicing-mutation c.416-1G<A were found, introducing p...

Nowadays, though highly improved, the efficiency of human assisted reproduction protocols remains affected by a decrease in embryo yields after IVF. The aim of the current study was to evaluate a possible relationship between poor embryos and the functionality of follicles stimulated to grow with exogenous gonadotrophins, using a monovular species (sheep) as a model. In ewes, follicles can ovulate from ≥6 mm in unstimulated cycles, but from ≥4 mm in FSH treatments....

Background: There aren’t published randomized studies comparing the clinical impact of degludec and Glragina U300 in the treatment of type 1 diabetes patients. (T1DP)Objective: To compare efficacy and safety of the new long acting analogues Glargine U 300 and Degludec in 300 Type1 diabetes patients treated with basal/bolus treatment.(BBT)Material and methods: Randomized control study 1.1 in 300 T1DP treated with BBT with glarg...

Aims: There are few data comparing oxidative stress markers in CSII versus MDI/G We compared after randomization CSII (Continuous subcutaneous insulin infusion) vs MDI/G therapy (multiple doses of insulin with glargine) in DM1 people previously optimized at MDI/G being the primary objective assessment of metabolic control and oxidative stress.Assess oxidative stress and metabolic control in patients with type 1 diabetes (T1D) after randomization in CSII ...