Endocrine Abstracts

Introduction: A key factor in the progressive increase in the prevalence of obesity is poor dietary habits. The treatment of obesity with regular diets often fail, so knowing the specific habits of these patients can be very useful to individualize treatment.Objective: Evaluate the dietary habits of subjects consulting for obesity in our clinic of Endocrinology and NutritionMaterials and methods: We conducted a survey of eating hab...

Introduction and objetives: There are few data in literature about the effects of rosuvastatin in patients with familial hypercholesterolemia in Spain. The objective of this study has been:1-to evaluate the efficacy and security of rosuvastatin in patients with familiar hypercholesterolemia2-to test the hypothesis that patients with diabetes have different response to treatment with rosuvastatin.Material and ...

Introduction: Patients with bariatric surgery require close monitoring because of possible metabolic complications. It has been published some cases of severe and persistent hypoglycemias resistant to diet and pharmacologic treatment being necessary a pancreatectomy. We present a case report of nesidioblastosis after gastric bypass that required subtotal pancreatectomy but despite this, hypoglycemias persisted. Before performing total pancreatectomy we placed a tube feeding in...

Background: Dopamine agonists are first-line agents for the treatment of prolactinomas and sometimes are used in patients with acromegalia. There is evidence that these drugs, especially cabergoline, are associated with an increased risk of new cardiac valve regurgitation in patients treated for Parkinson’s disease.Objective: Our objective was to evaluate the prevalence of cardiac valve regurgitation in patients with prolactinomas and acromegalia tr...

Objective: Calculation of accurate insulin boluses is one of the major problems related to intensive insulin regimens. A bolus calculator (BC) incorporated into the insulin pump estimates the dose of insulin to be administered at the meal and makes calculation easier and more precise.The aim of the present study was to assess the efficacy of a BC on glycaemic control of patients with DM1 on CSII.Material and methods: We enrolled 20...

Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency (21OHD) is the commonest inborn error in steroid biosynthesis. It is caused by mutations in the 21-hydroxylase gene (CYP21A2). A good genotype–phenotype correlation exists allowing for prediction of the expressed adrenal phenotype. We performed functional and structural analysis of six novel CYP21A2 variants (p.Trp22Cys; p.Asp184Asn; p.Leu198Phe; p.Val305Gly; p.His310Asn; p.Thr443Asn), i...

Efficiency of superovulatory protocols in ruminants is affected by occurrence of several reproductive abnormalities, such as anovulatory follicles (Kafi and McGowan 1997, Animal Reproduction Science, 48:137-157). The aims of current study were to characterize, in sheep, the incidence and possible causes of anovulatory follicles, their endocrine functionality in terms of oestradiol production and possible effects on viability of embryos from other follicles. The number and size...

The KINGS mouse harbours a mutant Ins2 which drives beta cell ER stress, however only males develop diabetes. Since diabetes incidence is lower in women and ER stress is implicated in human diabetes, we investigated the influence of oestrogen and testosterone in mediating sex differences in the KINGS mouse. To investigate the influence oestrogen (E2) and testosterone removal on glycaemic control, male (n =4-6) and female (n =9) KINGS mice underwent p...

Introduction: The T-Coach® telephone support program for patients with type 2 diabetes (DM2) treated with insulin glargine 300 u/ml, facilitates dose adjustments of basal insulin therapy through regular telephone consultations and offers diabetes education in order to improve empowerment of the patient. Objective: To assess the usefulness of the T-Coach® program in metabolic control and degree of satisfaction in patients with T2DM.Patients and ...

Introduction: The parathyroid gland is made up of principal cells and oxyphilic cells, surrounded by stroma, whose main component is adipose tissue, which accounts for 25% of the content of the parathyroid in adults. In parathyroid adenomas, prominent parathyroid cellularity can be observed, with a very marked decrease in the stroma. Parathyroid lipoadenoma is a rare variant of parathyroid adenoma, characterized by hyperfunctioning parathyroid cells in an abundant fatty stroma...