Endocrine Abstracts

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL12 is a proinflammatory cytokine with proatherogenic properties. IL12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL12. The aim of the present study was to investigate the influence of ...

Introduction: A high prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism has been described in adult women with type 1 diabetes mellitus (T1DM). Anti-Müllerian hormone (AMH) is secreted by granulosa cells of antral ovarian follicles and its plasma concentration is correlated with the number of small antral follicles. AMH levels are increased in women with PCOS and higher plasma concentration has been observed in prepubertal girls with T1DM. The aim of this...

Introduction: Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control in central nervous system. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signaling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130, respectively). sIL-6R sensitizes cells to...

Introduction: It has been recently suggested the genetic predisposition to obesity leads to increased risk of type 2 diabetes by its obesity predisposing effect. Surprisingly genetic loci that contribute to the development of obesity identified by genome-wide association studies (GWAS) account for only 2% of the variance in BMI. Visceral fat accumulation has an important role in increasing the risk of developing metabolic disorders, such as type 2 diabetes, dyslipidemia and CV...

Clinically non-functioning pituitary adenomas (CNFPA) represent a heterogenous group of tumors. Most of CNFPA are aggressive, usually diagnosed relatively late and surgery often fails to achieve the complete excision of tumor and the recurrence rate is high. About 80% of CNFPA are characterized by intense expression of somatostatin receptors (SSTR) inspiring use of somatostatin analogs (SSTa) in the medical cure of CNFPA. Scintigraphy with visualization of SSTR2 expression and...

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and prevent evolvement to overt hyperthyroidism. Material and methods: We treated 950 patients, aged 30–70 years; 87% of them were female and 13% male; 320 patients with multinodular goitre (MNG), and 630 patients with autonomous nodule (ATN). Some of the patients were treated with antithyroid drugs for 1 to...

Subclinical hyperthyroidism (SH) is characterised by supressed serum TSH concentration accompanied by fT3 and fT4 levels maintained within their reference ranges. The vascular endothelium as a specific target of thyroid hormones is strongly affected in hyperthyroidism. We aimed to compare the alterations of the endothelial function, haemostatic and inflammatory parameters in patients with SH in comparison with overt hyperthyroidism (OH) due to Graves’ disease and toxic no...

We treated 4150 patients, aged 30–70 years; 1950 patient with toxic multinodular goitre (TMNG), and 2200 patient with autonomous toxic nodule (ATN). Qualification of these patients was based on high levels of serum fT3 and fT4, low levels of serum TSH. Malignant changes were excluded in all nodules by fine needle aspiration biopsy. All the patients had serum TSH levels ≤0.1 mU/l and the effective T-half was ≥3 days at the time of treatmen...

Insulin resistance and type 2 diabetes are associated with an increased risk of neurodegenerative diseases. Brain-derived neurotrophic factor (BDNF) regulates neuronal differentiation and synaptic plasticity and its decreased levels are supposed to play a role in the pathogenesis of Alzheimer disease and other disorders. Decreased circulating BDNF levels in obesity and type 2 diabetes were reported, however, it is unclear, whether BDNF might be associated with insulin resistan...

Oxidative stress plays an important role in hyperthyroidism-induced tissue damage. We aimed to determine whether radioiodine therapy has benefit effect on the oxidant and antioxidant status in patients with Graves’ Disease.Material and methods: We studied 30 patients with Graves’ disease, aged 18–48 years. 12 normal adult volunteers were studied as control group. All the patients were treated unsuccessfully by antithyroid drugs. The effect...