Endocrine Abstracts

Polycystic ovary syndrome (PCOS) and type 1 diabetes (T1DM) are accompanied by increased risk of atherosclerosis. A higher prevalence of PCOS in T1DM patients has been reported. Brachial artery flow-mediated dilatation (FMD) and intima media thickness of common carotid artery (IMT) are used to detect an early endothelial dysfunction.The aim of our study was to examine IMT and FMD in T1DM women with PCOS. We also estimated the relation of IMT and FMD to c...

Aim: Clinical studies in Hashimoto thyroditis (HT) confirm, that even a minor thyroid dysfunction is related to significant changes in body mass. Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver and adipose tissue. Stimulators of betatrophin, such as thyroid hormones are usually relevant to energy expenditure or thermogenesis. The mechanisms of action of betatrophin are still unknown. In the present study ...

Introduction and aims: To date we have had some evidence that betatrophin is associated with insulin resistance. Some studies have demonstrated that betatrophin levels are elevated in type 2 diabetes, obesity and gestational diabetes. It has been shown that in mice betatrophin significantly improves beta cell function and glucose tolerance. This is the first study on betatrophin in which pregnant women were observed during all trimesters and in postpartum period to evaluate it...

Background: Interleukin-15 and -6 play a role in an inflammation, autoimmune, infectious and cancerous processes. Their increased concentrations were observed in psoriasis, asthma, multiple sclerosis and type 2 diabetes. However, the role of IL-15 and IL-6 in autoimmune diabetes (AD) pathogenesis is still unknown.Aim: The aim of our study was to assay circulating IL-15 and IL-6 levels in newly diagnosed AD patients, their I° relatives and healthy co...

Introduction and aims: TGF-β1 participates in the pathogenesis of autoimmune diseases e.g. diabetes, Hashimoto disease, autoimmune digestive system disorders. The aim of our study was to evaluate TGF-β1 levels during pregnancy and after childbirth in women who developed postpartum thyroiditis (PPT) in comparison to the healthy control group (CG) and women with positive anti-thyroid antibodies (ATA+) who did not develop PPT.Material and method: ...

Introduction: The prevalence of polycystic ovary syndrome (PCOS) is increased in women with type 1 diabetes (T1DM) in comparison to the general population. It has been suggested that exogenous insulin administered to T1DM women in supraphysiological doses could act as co-gonadotropin and lead to disturbances observed in PCOS.Aim: The aim of this study was to evaluate the phenotypic characteristic and differences between diabetic women with PCOS (T1DM+PCO...

Purpose: Recent reports strongly suggest that at least some cases of Hashimoto’s thyroiditis (HT) may be closely associated with IgG4-related disease. In the present study we aimed to find out, whether the measurement of serum IgG4 allows for an identification of distinct types of HT, with different clinical, sonographic and serologic characteristics.Methods: The group studied consisted of 53 patients with HT and 28 healthy individuals. All the part...

Introduction: The transcription factor 7-like 2 gene (TCF7L2) has the strongest effect on the risk of type 2 diabetes but the mechanism for this is not fully understood. Some genetic variants are associated with pancreatic B-cell function and some single nucleotide polymorphisms show a significant correlation with obesity. The aim of the study was to analyze whether TCF7L2 variants may influence body weight and body fat content, as well as postprandial glucose metabolism in no...

Background and aims: In patients with type 2 diabetes, elevated tumor necrosis factor α (TNFα), C-reactive protein (CRP), chemerin, fetuin-A, have been reported. However, it is not entirely clear whether these alterations in adipokine serum concentrations are already present in prediabetic states and in type 1 diabetes. The aim of the study was to investigate whether adipokine profiles (chemerin, fetuin-A, TNFα) and inflammatory markers (CRP) are associated with...

Aim: It is well known that T1D is associated with other autoimmune diseases. The aim of this study was to compare the prevalence of various auto-antibodies in first-degree relatives of patients with T1D and healthy individuals with negative family history of diabetes.Material and methods: The group studied consisted of 90 relatives and 60 healthy individuals. Serum concentrations of antibodies to anti-21-hydroxylase (21-OH-Abs), anti-gastric parietal cel...