Endocrine Abstracts

Pancreatic neuroendocrine tumors (PETs) occurs in approximately 1 per 100 000 people per year and account for only 1–2% of all pancreatic tumors. Most of them are hormonally active, while about 30% secrete no detectable hormons and are discovered due to a tumor mass effect.Material and methods: We analysed 178 patients with neuroendocrine tumors (NETs) treated at our department in the last five years. The diagnosis was made by pathohistological exam...

Objectives: Insulin resistance and hyperinsulinaemia are implicated in the pathogenesis of the polycystic ovary syndrome (PCOS) in the majority of the cases. Adiponectin is adipose tissue-specific protein and its correlation with insulin resistance is well established. The aim of the study was to access the correlation between adiponectin and anthropometric and metabolic parameters in a group of women with PCOS.Methods: Thirty-one women with PCOS (age: 2...

Mutation Y791F of RET protooncogene is a well known mutation so far described in families with FMTC and familial pheochromocytoma in one family. It activates the receptor in a monomeric form. Here we present eight unrelated families with the same mutation but different fenotype expression.Patients and methods: In last 20 years, we analyzed 216 patients with MTC (age range: 3–75 years, 45.0 mean). Genetic testing for mutation in RET pro...

We describe a 52-year-old woman, with acromegaly, clival chondroid chordoma, meningioma and lung carcinoid. There was no family history of MEN-1. She was diagnosed as acromegaly in 2000. Radiological evaluation (MRI) revealed pituitary tumor, however, another infiltration of scull base was detected which invaded sphenoidal and ethmoidal sinuses, lamina cribroza and bilateral orbit walls. Pituitary tumor was completely removed and the reduction of extra-sellar mass was performe...

The diagnosis of adult growth hormone deficiency (GHD) in patients with pituitary disease relies predominantly on provocative tests of GH secretion. The incidence of GHD in treated acromegalic patients has not been fully documented. Therefore, the aim of the present study was to elucidate GH response to insulin-induced hypoglycaemia (ITT, 0.15 IU/kg i.v.) in a cohort of 10 patients with acromegly considered cured solely by transsphenoidal surgery (6 females and 4 males, mean a...

The aim of this study was to compare metabolic profile in hypertensive obese and lean subjects. The study population consisted of 76 patients. We measured fasting glucose and insulin levels, triglycerides, total, LDL and HDL cholesterol. We also estimated the BMI, WHR, systolic (SBP) and diastolic blood pressure (DBP). We used WHO criteria for abdominal obesity (WHR>0.90 men, >0.85 women), and WHO criteria for diagnosing the metabolic syndrome (triglyceride>1.7 mmo...

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk for cardiovascular disease. Aim of our study was to determine the frequency of cardiovascular risk factors using Framingham Scoring system (FSS) in PCOS and controls.Methods: FFS included age, value of cholesterol and HDL (mmol/L), smoking and systolic blood pressure (sysBP, mmHg). We also determined LDL (mmol/l), oxidized LDL (OxLDL, U/l) and triglycerides (mmol/l). We studied...

Introduction: Cortisol has important roles in the regulation of body composition and hypercortisolaemia have major impact on body fat distribution. The aim of this study was to analyze differences in adipose tissue distribution in women with Cushing’s disease and Cushing’s syndrome due to adrenal adenoma.Method: We evaluated 12 women with Cushing’s syndrome, six with ACTH secreting pituitary adenomas (Group A) and six with adrenal adenomas...

Introduction: Luteinizning hormone (LH/hCG) responsiveness has been documented in both normal and pathological adrenal glands, but it is unclear whether chronic exposure to LH could affect adrenal function by increasing LH receptor (LHR) expression.Subjects and methods: We studied 12 postmenopausal women with previously documented adrenal tumor. All patients underwent standard hormonal testing for assessment of tumor functionality. Then hCG test was perf...

Adrenocortical carcinoma (ACC) is rare malignancy associated with poor prognosis. The aim of this study was to present clinical characteristics and survival of patients with ACC and to analyse the effect of prognostic factors on survival.We retrospectively analysed 69 patients (46 female and 23 males) with pathologically confirmed ACC who were treated in our hospital between January 2005 and December 2015. The median age at diagnosis was 51,0 years (rang...