Endocrine Abstracts

Introduction: Cushing’s syndrome (CS) is rare in children. The most common cause of CS in children is exogenous or iatrogenic CS. The most common cause of endogenous CS is Cushing disease (CD). Pediatric CD is almost always caused by a pituitary microadenoma. Here we present a rare case of (CD) related to pituitary macroadenoma.Clinical observation: An 11 year old boy presented with complaints of excessive appetite and progressive weight gain. He ha...

Introduction: 11β-Hydroxylase deficiency (11β-OHD), caused by CYP11B1 mutations, is characterized by hyporeninemic, hypokalemic hypertension and hyperandrogenism. We studied the mutations of CYP11B1 gene in two patients with classic 11β-OHD.Observations: We present the first case of a 23 year old boy with preliminary diagnosis of 21 β-OHD diagnosed at the age of 10. The patient presented with hypertension and hypokalemia which were ag...

Introduction: Dopamine agonist resistance is rare in prolactinoma (10%). Doses of cabergoline of up to 2.0 mg/week are usually effective in controlling prolactin (PRL) secretion and reducing tumor size. Surgical treatment is rarely indicated.Case report: An 18-year-old female presented in 2002 with a 2-year history of amenorrhea and galactorrhea. Hormonal investigation showed a hyperprolactinemia (4800 mUI/l) with integrity of the other pituitary axis. T...

Introduction: Weight loss is a mainstay in the treatment of polycystic ovary syndrome (PCOS). While the cause of this complex endocrine disorder remains unknown, it’s approved that weight loss improves symptoms of PCOS. We report a case of a patient with PCOS. Her symptoms disappeared totally after losing 50kgCase report: In 2005, a 16-year-old girl presented for evaluation of spaniomenorrhoea and obesity. Physical examination showed a weight of 88 ...

Introduction: While prolactin is most well known for its role in lactation and suppression of reproduction, its physiological functions are quite diverse. There are many etiologies of hyperprolactinemia, including physiologic as well as pathologic causes. Factitious hypoglycemia a rare case of induced hyperprolactinemiaCase report: We report a case of 17-years-old girl presented to with sever hypoglycemia mesured at 30 mg/dl. The patient had no significa...

Introduction: Ceylon cinnamon (CC) has shown its interest in insulin resistance, type2 diabetes and weight loss. In this study, we aimed to evaluate the effects of CC on anthropometric indices in patients with polycystic ovary syndrome (PCOS).Methods: We performed a prospective interventional study, including 13 patients with PCOS, diagnosed according to the Rotterdam criteria, patients having received neither diet education nor Metformin. At T0 all our ...

Recently, special attention has been paid to the relationship between doctors and the pharmaceutical industry. The aim of this work was to evaluate the attitude of Tunisian endocrinologists towards pharmaceutical promotion.Methods: It was a cross-sectional study based on an anonymous 9-item survey about the attitudes and behaviors of physicians towards the pharmaceutical promotion. The study included 120 participants.Results: One-t...

Introduction: The most common cause of diabetes insipidus is idiopathic. In some rare cases, it can be secondary to metastasis to hypothalamic–pituitary region.Case report: We report a case of 68-years-old female patient presented to our clinic with complaints of polyuria and polydipsia. She had medical history of breast adenocarcinoma 6 years ago treated with surgery, neoadjuvant radiotherapy and 8 cycles of chimiotherapy. On physical examination ...

Introduction: Insulin resistance (IR) is the main pathogenic factor in polycystic ovary syndrome (PCOS) and its complications. Ceylon cinnamon (CC) is an herb with an insulin-sensitizing effect reported in diabetic patients.The aim of our study was to assess the efficiency of CC on the parameters of the IR in patients with (PCOS).Methods: We conducted a prospective interventional study, we included 13 patients with PCOS diagnosed according to the Rotterd...

Introduction: Type 1 diabetic women have generally more menstrual disorders than healthy women.Objectives: Identify the main mechanisms responsible of menstrual disorders in type1 diabetic women.Patients and methods: We conducted a comparative transversal study including 70 patients with type 1 diabetes: Thirty-three having menstrual disorders (group M) and 37 with regular menses (control group T).We compared...