Endocrine Abstracts

IntroductionGrowth hormone deficiency (GHD) is a rare cause of statural retardation in children. The diagnosis is evoked in front of a bundle of anamnestic, clinical and radiological arguments. Treatment consists of substitution by recombinant GH with the aim of restoring normal size. There is interindividual variability in the response to treatment. We therefore proposed to study the response to treatment as well as the predictive factors of this respon...

IntroductionCongenital GH deficiency is more common in boys than in girls. Several differences have been noted between the 2 genders. We proposed to study these differences for epidemiological, auxological and anthropometric characteristics.MethodsThis is a retrospective study including 75 patients followed for congenital GH deficiency in the endocrinology department at the National Institute of Nutrition in ...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine pathology in women with a high prevalence varying between 5 and 20%. Autoimmune thyroid diseases (AITD) are the most prevalent organ-specific autoimmune diseases, particularly in young women. The purpose of our study was to determine the prevalence of AITD in a group of patients with PCOS compared to a control group.Patients and Methods: 103 women were recruited into the study, aged bet...

Introduction: Metformin is a cornerstone in the treatment of type 2 diabetes, but in recent years several studies have shown that metformin use is associated with a 4-24% decrease in vitamin B12 levels. It is estimated that this problem occurs in approximately 10-30% of patients using metformin and may contribute to distal symmetrical polyneuropathy (DSPN), a very common and clinically relevant diabetic complication.Objective: To study vitamin B12 concen...

Introduction: Several studies have evaluated the prevalence and impact of metformin induced vitamin B12 deficiency in type 2 diabetes patients. On the other hand, low vit B12 was associated with adverse lipid profile.Aim: To evaluate the relationship between vitamin B12 deficiency and the lipid profile in patients with neuropathy.Patients and methods: A cross-sectional study included 123 type 2 diabetic patients treated with metfor...

Introduction: Diabetic retinopathy (DR) is a serious microvascular complication of type 2 diabetes and the leading cause of blindness worldwide. Several studies have reported the association between metformine-induced vitamin B12 deficiency in type 2 diabetic patients. However, the association between vitamin B12 and DR has only been investigated in few studies.Materials and methods: A cross-sectional study was carried out on 123 type 2 diabetic patients...

The Miller-McKusick-Malvaux (3M) syndrome is a primordial growth disorder characterized by low birth weight, reduced birth length, severe postnatal growth restriction, a spectrum of skeletal anomalies, facial dysmorphism and normal intelligence. Mutations in the CUL7 gene (6p21.1) are most often responsible for 3M syndrome (67% of cases). Other causal mutations include those in the OBSL1 gene (2q35), in 28% of cases, or the CCDC8 gene (19q13.33), in ...

Introduction: The pathophysiology of diabetic nephropathy is characterized by proteinuria which often precedes the decline in creatinine clearance. The objective of our study was to describe the clinical and metabolic characteristics of a population of diabetic femele patients with renal failure without proteinuria.Methods: This is a retrospective study that included 37 diabetic women who had been hospitalized at the National Institute of Nutrition of Tu...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder. The presence of polycystic ovarian morphologyis usually confirmed by ovarian ultrasound. However, its definition is controversial. The objective of this study was to evaluate the interest of the antimullerian hormone (AMH) in the diagnosis of PCOS, aiming to establish a threshold that would be predictive of PCOS among Tunisian women.Patients and Methods: Sixty-twoyoung women (...

Introduction: Latent autoimmune diabetes in adults (LADA) is a genetically linked, autoimmune form of type 1 diabetes mellitus (DM) that accounts for 2–12% of all cases of diabetes.The goal of our study is to detect LADA among patients who were diagnosed as type 2 DM and who became insulin requiring.Methods: Our study included 45 patients (15 men, 30 women) diagnosed as type 2 DM, who had a poor glycemic control on oral hypogl...