Endocrine Abstracts

Background: Tamoxifen is a partial estrogen agonist used to treat estrogen receptor positive breast cancer. It has been discovered however that resistance to tamoxifen develops in some cancers. In order to investigate the mechanisms underlying the development of resistance we have created a tamoxifen resistant breast cancer cell line.Aims: To develop a breast cancer cell line that is resistant to the anti-growth effects of tamoxifen.<p class="abstext...

Background: The pro-proliferative and anti-apoptotic IGF-I is implicated in the development of colorectal cancer (CRC) in both the general population and patients with acromegaly. The local intracolonic environment is also likely to be important, particularly unconjugated bile acids such as deoxycholic acid (DCA). Whilst low faecal concentrations may be proliferative, high levels are toxic to colonic epithelial cells.High levels of DCA have been linked t...

Background. Recent studies have linked high serum levels of IGF-1 and low levels of IGFBP-3 with an increased risk of colorectal cancer. BP3 has been shown to have IGF-1 independent effects on cell proliferation in breast and prostate cells, but its effects on colon cancer cells is largely unknown. Aims. To determine: 1) the effects of BP-3 on colonic epithelial cell proliferation and apoptosis, and 2) whether any effects are independent of IGF-1. Methods....

Background and aimDiabetes is the leading cause of adult blindness due to retinopathy. Serum uric acid levels independently predict the development of micro vascular complications. In this study, we analyze the relationship between serum uric acid (SUA) levels with the development and the severity of diabetic retinopathy(DR) in patients with type 2 diabetes mellitus (T2DM).Patients and MethodsA total of 100 T...

Background and aimHyperuricemia is linked to a variety of diseases such as atherosclerotic cardiovascular disease (ASCVD). There are controversial data concerning the significance of high-normal values of serum uric acid (SUA) in patients with T2DM and cardiovascular disease. The aim of the study is to assess SUA levels in Type 2 diabetes mellitus (T2DM) patients with ASCVD.Patients and methodsThis retrospect...

BackgroundThere is a well-recognized association between diabetic retinopathy (DN) and diabetic nephropathy (DN), in which nephropathy without retinopathy is rare but retinopathy without nephropathy is common.AimTo highlight the discordance between retinopathy and nephropathy and describe a series of patients with diabetic nephropathy who had no evidence of diabetic retinopathy.Methods<...

IntroductionThe combination of at least three autoimmune diseases in the same patient is defined as multiple autoimmune syndrome. Recent studies demonstrated a higher prevalence of celiac disease in patients with immune thrombocytopenia when compared to the general population. Here we report the occurrence of celiac disease, Hashimoto’s disease and immune thrombocytopenia in type 2 diabetes patient.Case report<p class="abs...

Background and aimAbundant evidence suggests an association between thyroid disease and type 2 diabetes mellitus (T2DM). To determine the interaction between these co-existing pathologies, we analyzed insulin-treated type 2 diabetes patients with diagnosed thyroid disease.Patients and methodsThis retrospective study was performed in 54 type 2 diabetes patients who had been admitted for insulin-treatment and d...

BackgroundCeliac disease (CD) occurs in patients with type1 diabetes (T1DM) ranging the prevalence of 4.4–11.1% versus 0.5% of the general population. The mechanism of association of these two diseases involves a shared genetic background.AimTo investigate whether in type1 diabetes (T1DM) patients the concomitance of treated celiac disease (CD) impacts glycemic control and the prevalence of microvascular...

Background and aim: Gestational Diabetes Mellitus (GDM) is the commonest medical pregnancy complication. Nutritional interventions come to the fore as one of the few levers for managing GDM, as many medications are either harmful to the growing fetus, or their toxicity is uncertain. The aim of this study was to assess the potential clinical features and nutritional risk factors of insulin treatment during GDM.Methods: This was a prospective study includ...