Endocrine Abstracts

Introduction: Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine which is associated with obesity, insulin resistance and cardiovascular disease. It is supposed that insulin has anti-inflammatory action. The aim of the present study was to estimate serum IL-18 concentration in young healthy population, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation.Methods: We studied 36 h...

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL12 is a proinflammatory cytokine with proatherogenic properties. IL12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL12. The aim of the present study was to investigate the influence of ...

Introduction: A high prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism has been described in adult women with type 1 diabetes mellitus (T1DM). Anti-Müllerian hormone (AMH) is secreted by granulosa cells of antral ovarian follicles and its plasma concentration is correlated with the number of small antral follicles. AMH levels are increased in women with PCOS and higher plasma concentration has been observed in prepubertal girls with T1DM. The aim of this...

Introduction: Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control in central nervous system. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signaling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130, respectively). sIL-6R sensitizes cells to...

The pentagastrin-stimulated calcitonin test is known and widely used in monitoring patients with MTC. Given the problems of pentagastrin availability other diagnostic tests are being tried.The goal of the study was the evaluation of safety and tolerance of high-dose calcium to stimulate calcitonin in MTC patients.Materials: The study included 41 patients after surgery for medullary thyroid cancer who were under observation. Patient...

Introduction: The Pg calcitonin stimulation test is widely used in monitoring patients with MTC. In view of accessibility problems of Pg it is necessary to use high doses of calcium as the calcitonin stimulant.Objective: The aim of the study was the comparison of calcitonin concentrations after Pg and calcium stimulation, respectively.Materials: The study was performed in 31 patients under observation after deemed surgically cured ...

Introduction: Calcitonin is the main MTC marker. However, it has limitations: rapid in vitro degradation, a concentration-dependent biphasic half-life, presence of different isoforms and high cost of a single trial. Other markers of MTC can be procalcitonin and ProGRP.Aim: The aim of the study was to evaluate the diagnostic performance of marking the levels of procalcitonin and ProGRP in monitoring patients with MTC.Material...

Insulin resistance and type 2 diabetes are associated with an increased risk of neurodegenerative diseases. Brain-derived neurotrophic factor (BDNF) regulates neuronal differentiation and synaptic plasticity and its decreased levels are supposed to play a role in the pathogenesis of Alzheimer disease and other disorders. Decreased circulating BDNF levels in obesity and type 2 diabetes were reported, however, it is unclear, whether BDNF might be associated with insulin resistan...

Introduction: Case reports of individuals with non-insulinoma hyperinsulinic hypoglcaemia of organic origin has been more frequently described in literature. This syndrome has been described as a rare complication of bariatric surgeries and the term of NIPHS (non-insulinoma pancreatogenic hypoglycemia syndrome) has been proposed.Aim: The aim of our study is to present patients case who had previously undergone the gastric surgery. Bilroth II and finally ...

Visfatin, a protein secreted by the adipose tissue, might regulate insulin action. The aim of the present study was to assess serum visfatin concentration in obese women with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) and to estimate the relationships between serum visfatin concentration and insulin sensitivity, blood pressure, proinflammatory and proatherogenic factors.The study group consisted of 134 women: 30 overweight or obe...