Endocrine Abstracts

Introduction: Undetectable concentration of Tg after rhTSH stimulation (Tg/rhTSH) is one of the most important criteria in evaluating the effectiveness of radioiodine ablation in patients with differentiated thyroid cancer (DTC) treated with 131I.Aim: To evaluate the possibility of using L-T4 suppression treatment (Tg/L-T4) measurements by the ultrasensitive method TRACE (immunofluorescence method) with the KRYPTOR analyzer instead of the Tg/rhTSH measur...

We report the case of 57-year-old man with end-stage renal disease, primary hyperparathyroidism and after an surgery of upper parathyroid glands with ectopic parathyroid localized in lung. Patient was directed to our hospital to perform diagnostics on hyperparathyroidism. Two years earlier (2011) patient was hospitalized because of weakness and weight loss, and was diagnosed with primary hyperparathyroidism. In 2012 he underwent the bilateral parathyroidectomy of upper glands ...

Introduction: Treatment of Graves orbitopathy (GO) is one of the most difficult problems in clinical endocrinology. Objective: To establish the efficacy of the regime used in the treatment of GO and to analyze methods used to determine treatment effectiveness.Material: The study involved 30 patients with moderate to severe GO (according to the classification of EUGOGO) being in the active phase of GO.Method: ...

Background: The activating somatic point mutation, BRAFV600E, is the most common genetic alteration observed in papillary thyroid carcinoma (PTC) but its oncogenic role in PTC has been extensively investigated. Numerous studies reported that BRAFV600E correlates with poor clinical outcome, whereas others have found no such association. It is estimated that BRAFV600E occurs in ~ 45–50% of PTC cases, but recent studies showed the more freque...

Introduction: Postoperative thyroglobulin (TgPO) has a well established position as the prognostic factor for the follow-up of patients with differentiated thyroid cancer (DTC) after total thyroidectomy. However, the presence of thyroid remnants after surgery may diminish predictive value of TgPO.The aim of the study is to evaluate prognostic value of stimulated postablative thyroglobulin level (TgPA) measured after 6–9 months after radioacitve iodi...

Objective: It has been shown that women with PCOS as well as with autoimmune thyroiditis (AIT), are characterized by increased incidence of infertility. Serum anti-Müllerian hormone (AMH), which reflects ovarian reserve, is elevated in PCOS women and is decreased in women with AIT. The Rotterdam criteria recognize four clinical PCOS phenotypes,i.e.,phenotype Acharacterized by clinical and/or biochemical hyperandrogenism (HA), menstrual dysfunction (oligo/amenorrhea) (Olig...

Introduction: Adiponectin is an adipocytokine with insulin-sensitizing and anti-inflammatory properties. In skeletal muscle, it increases fatty acid oxidation and insulin-stimulated glucose uptake through binding with adiponectin receptor 1 (AdipoR1). The aim of our study was to assess the effect of insulin and Intralipid/heparin infusions on muscle AdipoR1 expression in humans.Methods: Twenty healthy male subjects (age 25.2±3.2 years; BMI, 26.5&#17...

Introduction: Glycoprotein 130 (gp130) cytokines, like interleukin 6 (IL6), act through plasma membrane receptors consisting of two glycoproteins: a cytokine binding subunit (like IL6R) and gp130, responsible for signal transduction. IL6 may regulate insulin sensitivity in a dual manner, as both insulin-sensitizing and -desensitizing actions have been reported. Other gp130 cytokines may have a beneficial metabolic effects. The aim of the present study was to assess skeletal mu...

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL18 is a proinflammatory cytokine with proatherogenic properties. Existing evidence indicated that circulating IL18 was associated with insulin resistance, metabolic syndrome and type 2 diabetes. Some data suggest that endogenous IL18 signaling modulates food intake, metabolism and adiposity, as homeostatic regulator. The aim...

Introduction: The correct 25-hydroxy vitamin D (25(OH)D) level plays a key role in the proper supply of vitamin D for the organism. Vitamin D deficiency may lead to an increased risk of development of various neoplasms, including papillary thyroid carcinoma (PTC).Aim: Evaluation of the prevalence of vitamin D deficiency in patients with PTC and analysis of the relation between 25(OH)D levels and age, sex, place of living, severity of the disease, and pre...