Endocrine Abstracts

Iatrogenic Cushing syndrome caused by the use of steroid medications is common because of the widespread use of these medications for the treatment of many diseases, however development of Cushing syndrome from the topical corticosteroids is very rare in adults.A 45-year-old men (BMI: 44 kg/m2), with a history of psoriasis, developed manifestations of Cushing syndrome, which included weight gain, central obesity, moon face, facial plethora, bu...

Introduction: Prolactin is a hormone which is characterized with a high structural and functional polymorphism. Macroprolactin is one of the form of prolactin - it is a complex of monomeric prolactin and immunoglobulin. Macroprolactin is characterized with immunoreactivity and probably the lack of biological activity.Purpose: The main purpose of our study was to estimate the frequency of macroprolactin appearance among the patients with hyperpronactinaem...

Objective: Hypothyroidism is one of the most common disturbances of thyroid function caused by a thyroid hormone deficiency, found predominantly in young women. The general slowdown of metabolic processes and low-grade chronic inflammatory state occurs in the broad spectra of clinical hypothyroidism manifestations. Although several risk factors of hypothyroidism have been identified, the exact pathogenic mechanisms remain unexplained. The conventional treatment of hypothyroidi...

Introduction: Primary hyperparathyroidism (PHPT), as a state of chronic hypercalcemia, can be manifested by non-typical symptoms which can delay the proper diagnosis for many years and lead to serious preventable complications affecting the patient’s quality of life.Case report: A 52-year-old woman with hypertension, thyroid nodular goiter treated with radioactive iodine and a 20-year history of gastric and duodenal ulcerative disease, complicated b...

Introdutcion: In recent years, thyroid microcarcinoma (TMC) predominates in the context of diagnosis and treatment of thyroid cancer. TMC has an excellent prognosis, its management is changed in the last few years, reducing surgical procedure and role of radioiodine ablation (RAI). Therefore, the question is what tests have a diagnostic value in patients with thyroid microcarcinoma after thyroidectomyThe aim of this study was to evaluate the role of 131 ...

Introduction: Adrenocorticotropic hormone (ACTH) is a tropic hormone produced by the anterior pituitary that stimulates the adrenal glands to release cortisol. The ACTH measurement is often used to diagnose the pituitary and/or adrenal disorders, mainly Cushing’s disease, Cushing’s syndrome, Addison’s disease and hypopituitarism. Therefore, the assessment of plasma ACTH concentration is a crucial step in the differential diagnosis of hypothalamic–pituitary&...

Introduction: Studies demonstrate that non-functioning adrenal incidentalomas are assosiated with increased risk of diabetes mellitus and cardiovascular diseases. Chronic inflammation plays key role in developing type 2 diabetes, as well as cardiovascular diseases.Aim: The purpose of the study was to evaluate new anthropometric parameters (BAI, LAP, VAI, BRI, ABSI, RFM) and its relationship with inflammation indicators (PLR, MPVLR, SII) among patients wi...

Introduction: Omentin is a visceral fat tissue adipokine which regulates metabolism (insulin sensitivity) and presents an anti-inflammatory activities, by lowering C-reactive protein concentration, in obesity and diabetes mellitus type 2. Polycystic ovary syndrome is the most common endocrinopathy in women of childbearing age. One of the major disorders in the PCOS metabolic phenotype is obesity and hyperinsulinaemia. The anthropometric indicators are useful tools for carbohyd...

The accumulated data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and high risk of developing prediabetes and diabetes. The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of insulin resistance and insulin secretion in women with PCOS, comparing to the control group. The study group comprised 43 women with PCOS and 16 controls matc...

: The observed increase in the incidence of Hashimoto’s thyroiditis (HT) requires research on factors that may affect its development. One of them may be vitamin D deficiency which is an epidemiological problem all over the world.Aim: The assessment of influence vitamin D deficiency on the HT activity.Material and methods: 310 people were enrolled in the study: 155 patients with HT (a-TPO and/or a-TG positivity)-144 women (93%...