Endocrine Abstracts

Introduction: Autoimmune thyroid diseases are frequent and very polymorphic pathologies. The same person can successively present with different manifestations. Graves’ disease and Hashimoto’s thyroiditis seem to be able to coexist. The name "Hashitoxicosis" has been suggested in this case, characterized by the sequential association, whatever the order, of hyper- and hypothyroidism. We report in this work, the case of a patient treated for autoimmune hypothy...

A 63-year-old female with cardiovascular risk factors presented with tremor, sweating, lower back discomfort, nausea and dyspnoea. ECG showed sinus tachycardia with lateral ST-depression. High-sensitivity troponin was dynamically elevated (72 ng/l to 112ng/l on one-hour repeat). Computed tomography aortogram ruled out aortic dissection but identified a 6.6cm lesion in the left adrenal gland. Ventricular tachycardia was detected on cardiac monitoring. Differential diagnoses inc...

Introduction: Transsphenoidal surgery (TSS) is the first-choice treatment in Cushing’s disease (CD) with an immediate success rate of 70-80%. Unfortunately, due to the high rate of post-operative recurrences, CD patients require life-long surveillance. However, there is no consensus on how to follow these patients after TSS to early diagnose relapses. The aim of the study was to find reliable predictors of recurrence after neurosurgery in CD.Materia...

Introduction: Tumour cachexia-anorexia syndrome (CAS) is a complex disorder characterized by progressive nutritional and metabolic alterations that lead to loss of muscle and adipose tissue observed in advanced-stage cancer. CAS indicates unfavourable prognosis, regardless of cancer type. Under the influence of permanent aggression, we have evaluated the effects of the cancer cachexia development on the hypothalamic-pituitary-adrenal (HPA) axis.Methods: ...

Introduction: Ultrasound-guided fine needle aspiration biopsy (US-FNAB) enables selective sampling of thyroid follicular cells while minimizing potential complications. Inadequate specimen sampling can lead to FNAB repeat. Our aim was to evaluate the morphological and cytological characteristics of thyroid nodules with US and rapid on-site evaluation of adequacy (ROSE).Methods: Two independent endocrinologists evaluated nodule characteristics of 171 US-F...

Background: Lithium salts have been widely known to induce thyroid dysfunction, however, parathyroid dysfunction due to lithium use is uncommonly encountered. Hypercalcemia is a relatively common consequence of lithium therapy presenting with nonspecific symptoms that may be overlooked. Although cerebral infarction may be an independent event from psychiatric disorders, it can also be a rare complication that must be recognized particularly in patients on lithium therapy.<...

New-onset diabetes after transplantation (NODAT) is a serious complication after a solid organ transplantation. It has been reported to occur in 4% to 25% of renal transplant recipients, 2.5% to 25% of liver transplant recipients, 40% to 60% of hepatitis C virus (HCV) infection and 2% to 53% of all solid organ transplantations. The diagnosis is performed using unmodified criteria for diagnosing diabetes in the general population and risk factors are the commonly recognized fac...

Introduction: Giant prolactinomas are rare tumours, representing 2–3% of all prolactin (PRL)-secreting tumours. Their definition is restricted to pituitary adenomas with a diameter ≥4 or ≥2 cm of suprasellar extension, very high PRL concentrations (≥1000 ng/ml) and no concomitant GH or ACTH secretion. They are more common in young to middle-aged men. Endocrine symptoms are often present for a long period of time, but most times the diagnosis is made when...

Objectives: Eversense XL is a fully implantable sensor for continuous glucose monitoring (CGM) that lasts for up to 180 days. Our objective was to perform a survey on user acceptance and satisfaction among our type 1 diabetic patients who had been using the Eversense XL CGM for at least 3 months.Methods: A questionnaire was devised in which the patients were asked about their experience with the Eversense XL CGM, including:-Compari...

Introduction: Central pontine myelinolysis (CPM) is a rare and potentially life-threatening complication of a sudden rise in serum osmolality. Along with extrapontine myelinolysis, it is part of the osmotic demyelination syndrome (ODS). Known risk factors include severe hyponatremia, alcoholism, thiazide use, hypokalemia, and malnourishment.Case report: We report the case of a 31-year-old-male with history of alcohol and cannabis dependence, who had atte...