Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting 5–10% of reproductive -age female population.The aim of this study was to determine the clinical features, metabolic and hormonal profile in obese and overweight women with PCOS.Patients and method: A total of 102 women (age 31.28±6.05 and BMI 33.02±5.93) with PCOS and 110 (age 32.35±4.96 and BMI 33.05±5.87) matched controls were invest...

Hypokalemic periodic paralysis is an uncommon complication of thyrotoxicosis especially in Caucasian women. It is most frequent in east asian and Japanese males and is characterized by recurrent episodes of motor weekness of variable intensity associated with hyperthyroidism. It is usually associated with low plasma potassium levels and is often precipitated by physical activity. This condition is a self limiting disorder that is cured by the treatment of the underlying hypert...

Thyroid dysplasia (ectopy, hypoplasia or aplasia) is a common cause of congenital hypothyroidism. Lingual thyroid is a rare embryological aberration caused by failure of migration of the thyroid gland to its normal position in the neck.This retrospective study involved 30 patients with lingual thyroid diagnosed in our Department between 1970–2005. The diagnosis was based on physical examination, evaluation of the mental development (IQ) and following tests:TSH, fT4, ultra...

Neurofibromatosis type 1 (NF1) is an inherited disorder characterized by formation of neurofibromas in the skin, brain and other parts of the body, in association with skin pigment changes. It is well known that this condition may be a risk factor for short stature with growth hormone deficiency (GHD) in children, due to suprasellar lesions. We present the case report of a 9-year-old boy admitted in our Service for short stature (-2DS). Physical examination revealed ‘caf&...

Hormonal treatment (HT) represents the only complete therapy of the consequences of the postmenopausal estrogenic deficiency. Quality of life in postmenopausal women is often compromised. We evaluated the quality of life (appreciated with IQL questionnaire) in 80 postmenopausal women – 40 with intact uterus, treated with natural estrogens associated with progestin, and 40 non-treated women. Group selection (treated/not treated) was made function of the inform consent of t...

Introduction: The Waterhouse–Friderichsen syndrome is a fulminating infection, often leading to mortality in a matter of hours by producing acute adrenal insufficiency (adrenal hemorrhage) at a time when their response is crucial to address acute stress.Case report: We present the case of a 4 months boy with high fever 40 °C, vomiting, diarrhea, lethargy, maculopapular rash followed by petechiae and purpura. Biological tests revealed important ...

Introduction: The adipocyte expansion is a critical process with implications in the pathogenesis of metabolic syndrome and insulin resistance associated to obesity. Impaired adipogenesis leads to dysfunctional, hypertrophic adipocytes, chronic low grade inflammation and insulin resistance.Methods: Our study included 18 obese patients (13 females and 5 males) mean age 38.76±8.89 years and mean body mass index 46.06±6.48 kg/m2, referred for Lapa...

Brown tumors (BT) consist of focal bone lesions, caused by increased osteoclastic activity and fibroblastic proliferation. They appear in chronic kidney disease (CKD) as a result of renal osteodystrophy with high bone turnover, due to secondary hyperparathyroidism. BT are composed of mononuclear stromal cells mixed with multinucleated giant cells and hemosiderin deposits, which give the characteristic brown colour. We present the case of a 13-year-old girl, with end-stage CKD ...

Gastrointestinal stromal tumors (GIST) are in high risk of developing additional malignancies, hereditary and also nonhereditary kind. Genetic changes are involved in the formation of GIST, about 80% are associated with KIT gene mutation and 10% of cases are associated with PDGFRA gene. These two mutations are found in both familial and sporadic GIST. We report a 65 years old female patient with a history of surgery for gastric GIST (T2N0). During the follow-up, after 4 years,...

The association between primary hyperparathyroidism and pheochromocytoma is present in multiple endocrine neoplasia type 2A (MEN 2A) along with medullary carcinoma or it can be a simple simultaneousness. The presence of the genetic mutation is mandatory in order to have a positive diagnosis of MEN. We report the case of a female patient 63 years old admitted in our department for a large adrenal incidentaloma (10 cm) with no clinical signs of adrenal dysfunction. An adrenal bi...