Endocrine Abstracts

Introduction: Lenvatinib is an oral tyrosine kinase inhibitor (TKI) used for treatment of progressive, clinically significant or symptomatic disease in patients with iodine-refractory differentiated thyroid cancer (DTC).Objective: To describe our clinical experience with lenvatinib in patients with iodine-refractory differentiated thyroid cancer.Methods: Restrospective cohort study of patients with iodine-refractory differentiated ...

Introduction: The use of mitotane as ACC therapy is associated with multiple adverse effects including hypercholesterolemia due to increased levels of LDL cholesterol. There are no reported cases of severe hypertriglyceridemia (HTG).Clinical case: A 59-year-old male with a personal history of dyslipidemia phenotype IV and pulmonary emphysema, former smoker and drinker was diagnosed with non-functioning left-sided ACC. Left adrenalectomy + left nephrectom...

The identification and characterisation of unique gene profiles expressed in specific adipose tissue depots around the body could provide novel insights on fat development.We report a comprehensive analysis of transcriptome from the five major (epicardial, pericardial, perirenal, sternal and omental) adipose depots from one week old sheep. This study also provides an integrated view of the preservation and differences between mitochondrial gene co-expres...

Background: Previous studies of association between maternal thyroid autoimmunity and adverse pregnancy outcomes have produced inconsistent results.Objective: To examine whether thyroid autoimmunity detected at first trimester screening is predictive of a range of adverse obstetric and fetal outcomes.Patients and methods: We studied 438 women with singleton pregnancies who underwent first trimester screening test between June and J...

Aims: To study if BRAF V600E mutation in thyroid fine needle aspiration (FNA) is associated with specific ultrasound (US) characteristics.Patients and methods: From 2010 to 2014 we reviewed patients with thyroid nodules with the following inclusion criteria: US guided FNA of the nodule and molecular testing for BRAF V600E on the FNA. BRAF mutation was detected using fluorescence melting curve. An expert on US, blinded to the BRAF status reviewed US exami...

Background: Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1-RA) whose role as a second-line treatment for patients with type 2 diabetes (T2D) has significantly increased. It has demonstrated cardiovascular safety and superiority in terms of glycaemic control and weight loss, compared to other GLP-1-RAs. The most common side effects are mild gastrointestinal, but it may also cause renal failure secondary to dehydration and an increased risk of diabetic retinopa...

Introduction: Growth hormone deficiency (GHD) is associated with worsening body composition and growth hormone replacement therapy (GHRT) has shown to improve it in several studies. The objectives of this study were to evaluate the effects of long-term GHRT on body composition in adult patients with GHD andassess, in this population, the agreement between two different methods to measure fat mass that are total body fat mass (FM) and relative fat mass (RFM).<p class="abste...

Introduction: Craniopharyngiomas are intracranial tumors that develop from Rathke’s pouch rests of epithelium. They have a bimodal age distribution, with peak incidence at childhood and in the adult/elderly, although in our series we have more patients in a middle peak. Usually they are benign but responsible for significant morbidity, particularly when located near critical structures such as optic chiasm, pituitary gland and hypothalamus, and thus might cause visual, ne...

Introduction: Bariatric surgery has proved to be effective in the management of morbid obesity. Our purpose was to compare the results obtained with adjustable gastric banding (GB) and Roux-en-Y Gastric Bypass (RYGB) during 2 years of follow-up after surgery, with regard to anthropometric parameters and related comorbidities.Methods: We evaluated prospectively patients who underwent GB and RYGB between 2004 and 2010 and compared the evolution of anthropo...

Obesity leads to low-grade inflammation, and high-fat diet is one of the major causes. On the other hand, menopause can aggravate it by promoting food intake alterations, and metabolic and endocrine adaptations. Thus, we used ovariectomized rats fed with high-fat diet to evaluate changes on the tissue inflammatory state. Forty days-old female Wistar rats were fed with: a hyperlipidic diet enriched with lard – H-group; or chow diet – C-group; for 30 days. After this p...