Endocrine Abstracts

Introduction: p53 is a transcription factor involved in many biological functions such as stress, ageing, and metabolism. Although there is a large body of evidence showing that p53 promotes fatty acid catabolism while it inhibits anabolism through the regulation of gene expression, the possible contribution of p53 to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains to be elucidated. Also, the anthracycline doxorubicin is an important chemotherapeutic agent...

Introduction: GH deficiency (GHD) leads to altered body composition, lipid metabolism and quality of life, and is also associated to an increased cardiovascular morbidity and mortality. The aim of this study was to evaluate long-term changes after treatment with GH replacement therapy (GHRT).Methods: We retrospectively reviewed adult patients with GHD in our clinic who were treated with GHRT. We evaluated demographic (etiology, age, dose), anthropometric...

Introduction: Graves’ orbitopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease. The first-line treatment are intravenous corticoids in active moderate-severe GO. Tocilizumab is a humanized monoclonal antibody against the IL-6 receptor which has been approved for the treatment of rheumatoid arthritis and is in its research stage for patients with corticosteroid-refractory GO.Objectives: To assess the experience with to...

Background: Lutetitum-177 (Lu-DOTATE) is an approved treatment regimen for patients with advanced neuroendocrine tumors (NETs). Improving patient experience is one of main goals of a cancer treatment plan. "Time-toxicity" describes the period that patients spend in doing administrative or medical procedures, including medical visits, scans, lab analyses, emergency room admissions, drug applications and hospitalizations. Modern therapies are usually approved after an im...

Introduction and aim: The current population is experiencing an increase in life expectancy, with a consequent change in the demographic structure of the society. It is common, therefore, to find elderly patients with pituitary neuroendocrine tumors (PitNET) in our usual clinical practice. Currently, there are no specific recommendations for treatment and data of outcomes in elderly are scarce. The aim of our study was to compare the clinical characteristics and surgical outco...

p53 family controls several metabolic and cellular functions. The p63 member regulates lipid metabolism in hepatocytes and contributes to the development of liver steatosis. Here we show that p63 plays an important role in liver fibrosis. P63 is upregulated in patients with NASH, correlating positively with fibrosis score and collagen 1a1 expression. P63 expression is also increased in different animal models of diet-induced NASH and chemically induced liver fibrosis. Mice wit...

Introduction: Gastroenteropancreatic neuroendocrine tumors have a highly variable presentation, which can range from benign neoplastic growths to rapidly aggressive malignancies. Neuroendocrine carcinomas of the digestive system are relatively rare. The incidence of GEP NEC in Spain is estimated to be 2.5 – five cases per 100 000 inhabitants.Case: We describe the case of a 67-year-old man, previously diagnosed with hypertension and dyslipidemia. He ...

Introduction: Bariatric surgery is associated with improvement and often resolution of type 2 diabetes mellitus (T2DM). Our aim was to compare the effects of gastric banding (GB) and gastric bypass (GBP) in glucose homeostasis in obese patients with T2DM.Methods: From 1995 to 2011, 83 diabetic patients underwent bariatric surgery at our hospital: 37 underwent GB (73% females, mean age 48.3±9.2) and 46 underwent GBP (82.6% females, mean age ...

Introduction: Funding of continuous glucose monitoring (CGM) has been established by Madrid Health Service for adults with type1 Diabetes Mellitus (DM) who meet specific criteria. This has brought to lightthe need foran increasedinvestment in care time. In our Division, a structured training program has been established, consisting of 2 training sessions (TS); the first one based on basic contents to initiateFlash-CGM, and the second one, more intensive and targeted, focused o...

Many mechanisms are proposed for green tea’s role as anti-obesity and anti-diabetic natural product. Two of them involve the hypothalamic control of energy balance: i) high-fat diets (HFD) rich in saturated fats induce low-grade inflammation, leading to leptin and insulin resistance; ii) serotonin receptors (SR) 1B and 2C activation have anorexigenic effects, SR2C activation improves insulin sensitivity, and HFD can also impair this system. We investigated the effects of ...