Endocrine Abstracts

Introduction: There are contradicting data about bone mineral density (BMD) in patients with type 2 diabetes mellitus (DM), although most studies describe increased BMD values in them. Due to this finding it is not clear how tightly bone fragility is bound with BMD in type 2 diabetic people.Design: We provided dual-energy X-ray absorptiometry of lumbar spine and proximal femur to 46 postmenopausal women with type 2 diabetes mellitus (DM), 14 of them had ...

Introduction: The diabetes mellitus (DM) is the known risk factor of fractures. The aim was to determine predictors of fractures in type 2 diabetic postmenopausal women without hyperparathyroidism.Design: We analyzed local trauma clinic data for 3 sequential years from 2 662 diabetic persons who were entered The National Register of diabetes mellitus patients (133 subjects with type 1 diabetes mellitus and 1995 ones with type 2 DM). Afterward we examined...

Background and aims: The aim was to determine psychoemotional state in diabetic and non-diabetic patients with or without fractures and its correlation with bone condition.Materials and methods: We examined 62 postmenopausal women with type 2 diabetes mellitus (DM), 29 of them had bone fracture within last month. The control group included 56 non-diabetic women, 26 within a group were recently fractured. Groups were comparable in body mass index, age, du...

Objective: The aim of the study was to assess the effectiveness and safety of long-term sibutramine therapy in routine clinical practice.Materials and methods: In total, 98 774 patients (82.3% women, 17.7% men), from 142 cities of the Russian Federation were enrolled in the PRIMAVERA program. The mean age of the patients was 39.39±10.38 years, the mean body weight was 99.1±14.28 kg, and the mean BMI was 35.7±4.41 kg/m2. Physicia...

Introduction: Measurement of copeptin is proposed for use in the differential diagnosis of polyuric syndrome.Aims: To evaluate the diagnostic value of copeptin levels in patients with polyuria syndrome.Materials and methods: The study included 17 patients with central diabetes insipidus (CDI), 3 patients with nephrogenic diabetes insipidus (NDI), 7 patients with primary polydipsia (PP) and 26 control subjects. In all individuals bl...

A 32-year-old woman presented with primary amenorrhea, prolactin (PRL) level of 154150 mIU/l (40–530 mIU/l) diagnosed with an endo-supra-infra-laterosellar giant pituitary adenoma measuring maximum 6.2 cm. The patient was prescribed a treatment with cabergoline (CAB) at an initial dose of 0.5 mg per week. The treatment decreased the tumour size and brought to normal the level of PRL. After 7 months of CAB treatment menarche was achieved, after 12 months the patient became...

Background: The SCOUT trial showed that sibutramine produced weight loss with some increased cardiovascular morbidity but not mortality. But these results should not be extrapolated to a routine practice as a lot of the SCOUT participants had contraindications for sibutramine. In order to summarise data on efficacy and safety of sibutramine administration in routine clinical practice according to approved indications and to implement risks monitoring system in Russia, PRIMAVER...

This study estimates the recovery of bone mineral density (BMD), markers of bone remodeling and quality of life in patients with endogenous Cushing’s syndrome (CS) after 12 months of remission.Materials and methods: Twenty-one patients with CS were prospectively evaluated at active stage of the disease and after being in a full remission (substitutional therapy with hydrocortisone or normal 24 h urinary free cortisol (24 h UFC) and late-night cortis...

Introduction: The important aspect of vitamin D (vitD) sufficiency is the impact of chronic diseases and medications, which disturb the metabolism of vitD. Bone pathology is common in diseases of the endocrine system, so the determining the status of vitD in various endocrine diseases and comparing it to otherwise healthy controls is of particular interest.Materials and methods: The study included 16 patients with type 2 diabetes mellitus (T2DM), 23 pati...

Background: Familial partial lipodystrophy type 2 (Dunnigan syndrome and FPLD2) is a rare genetic disorder, associated with different metabolic abnormalities, especially insulin resistant diabetes mellitus, dyslipidaemia, hepatic steatosis, and cirrhosis, cardiovascular disease, and cardiomyopathy, kidney disease.Clinical case: A 20-year-old patient first presented with changed appearance due to abnormal subcutaneous fat tissue redistribution (lipodystro...