Endocrine Abstracts

Introduction: Copeptin is a proposed new diagnostic marker in differential diagnosis of diabetes insipidus as it is secreted in equimolar concentrations with vasopressin. Thus our aim was to assess diagnostic value of copeptin evaluation in patients with polydipsic-polyuric disorders.Materials and Methods: We’ve evaluated the copeptin (BRAHMS CT-proAVP Kryptor), sodium levels and blood/urine osmolality in 26 healthy volunteers (1M/25F, mean age 24.7...

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is a rare, autosomal dominant disease caused by mutations in the MEN1 gene. The syndrome predisposes an individual to the development of primary hyperparathyroidism (PHPT), gastroenteropancreatic neuroendocrine tumors (GEP-NETs), pituitary adenomas (PA), as well as other endocrine and non-endocrine tumors that usually manifest at a young age. If a patient with the MEN 1 phenotype does not carry m...

The goal was todetermine the optimal methods of postoperative monitoring of serum thyroglobulin (Tg) in differentiated thyroid cancer (DTC). This research intended to compare the prognostic value of immunometric methods with different functional sensitivity (FS) for Tg measurement for detecting recurrent disease.Design: During 2010–2012 years, 76 patients with treated DTC (a total thyroidectomy and adjuvant radioiodine therapy) were included. All p...

In purpose to elucidate pathogenetic mechanisms of congenital forms of hypogonadotropic hypogonadism we have examined 25 women with idiopathic hypogonadotropic hypogonadism (IHH), mean age 26 years and 7 months (group 1). All patients had amenorrhea, little breast development (Tanner 2–3), absence or little axillery and pubic hair, infantile uterus and decreased ovary volume. There were no pathological changes during MRI-investigation. Twenty healthy women were included i...

Hypoestrogenemia is associated with dislipidemia and is an independent risk factor for cardiovascular diseases in postmenopausal women. However, there is a cohort of young women with gonadal steroid deficit caused by the disorders of central regulation. Twenty women with hypogonadotropic hypogonadism (HH) were included in group 1. (median age - 29 years and 3 months, median duration of amenorhea - 5 years 3 months, mean BMI - 24.6±6.05 kg/cm2. Women were examined before a...

Objective of the study: To examine risk factors for thyrotoxic cardiomyopathy (ThC).Methods: In retrospective study (1975 to 2003) 272 patients aged 54 [43; 62] years with different forms of toxic goiter in combination with cardiac rhythm disturbances with or without heart failure (HF) were included. Atrial fibrillation (AF) and/or atrial flutter and/or ventricular premature beats accompanied with HF were diagnosed in 80.5% (219/272) patients (group 1), ...

Molecular basis of the bone disorders in patients with acromegaly are largely unknown.Objective: To investigate microRNAs (miRNA) expression profiles that regulate bone metabolism in plasma samples from patients with acromegaly.Materials and methods: Fasting plasma samples were taken from consecutive subjects with biochemically confirmed active acromegaly and healthy volunteers matched by age, sex and BMI. IGF1 was measured by an e...

Background: Surgical outcomes in patients with acromegaly are highly dependent on a surgeon’s level of expertise, as the majority of patients present with macroadenomas at diagnosis.Aim: To assess remission rates in patients with acromegaly admitted to a tertiary medical center.Materials and methods: We included patients admitted to the neuroendocrinology and bone disease department with no previous radiation therapy or curren...

Introduction: Hypoglycemia is a decrease of glucose in blood, which can lead to coma and death. One of the causes of hypoglycemia in patients without diabetes mellitus (DM) is deliberate intake of hypoglycemic drugs (factitious hypoglycaemia, FH, Munchausen syndrome).Objectives: To present the psychosocial characteristics of patients with FH.Methods: Anamnesis analysis of 431 patients with hypoglycemia aged 18-93 years.<p class...

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate metabolism caused by a small mesenchymal tumor that secrete fibroblast growth factor 23 (FGF23). A 29-year-old female has suffered from two low-traumatic hip fractures, multiple fractures at the pelvic and sacrum, and diffuse bone pain for more than 3 years. Her mobility was limited in the last year (used crutches) because she had severe muscle weakness. Laboratory examination at the time ...