Endocrine Abstracts

Aim: To assess lipid levels in patients with PCOS and BMI >25.Materials and methods: 102 patients admitted to the Gynaecologic Endocrinology Clinic of the Jagiellonian University’s Collegium Medicum agreed to take part in this research, and PCOS, according to the Rotterdam criteria, was found in 87 of them. The control group consisted of 15 patients with FAI <5. All of the 87 patients had BMI >25. This index, as well as blood samples, we...

Polycystic ovary syndrome (PCOS) is a common endocrine abnormality connected not only with reproductive problems but also with impaired energy homeostasis leading to metabolic disorders including metabolic syndrome. Irisin (Ir), recently identified novel myokine, has been proposed to mediate some of the positive influence on metabolic disorders. The aim of our study was to search the relationship between Ir plasma concentration in PCOS in the context of metabolic disturbances....

Multidimensional studies of medical aspects of ageing were performed in 6 provinces of Poland, the protocol included cross sectional analysis of thyroid function parameters.The sample was randomly chosen and included 4,051 respondents (49.2% females).Group consisted of 3,502 elderly subjects aged 65–90+y, divided into approximately equal six age subgroups; and 549 younger cohort, aged 55–59 y.Thyroi...

Receptor for advanced glycation end-products (RAGE) signalling, crucial for diabetic macroangiopathy, is also highly suspected to be involved in atherogenesis in the setting of preserved glucose metabolism.Aim: To determine the relationships between peripheral blood concentrations of RAGE agonists, namely amfoterin (HMBG1) and carboxy-methylo-lisine (CML) as well as RAGE inhibitor Endogenously Secretory RAGE (esRAGE), and the severity of atherosclerosis ...

Some individuals with normal weight but probably visceral fat excess, called Metabolically Obese Normal-Weight (MONW), have disturbances typical for metabolic syndrome. We analyzed relationships between body fat distribution (estimated by DXA) and insulin resistance, serum inflammatory markers levels (CRP, IL-6, IL-18) and polymorphisms of IL-6 promoter and PPARγ in healthy, non-obese Polish subjects: 232 women (age 31.4±5.5; BMI 21.5±2.5) and 199 men (age 30.3&...

Introduction: Insulin resistance (IR) and visceral obesity, elements of metabolic syndrome (MS), contribute to hyperandogenaemia and may lead to hirsutism and other signs of hyperandrogenism. Little is known about the influence of metformin therapy (MET) on hormonal profile in women with MS and IR without menstrual irregularity.Aim: To asses the influence of MET on sex steroids concentrations in young women with MS.Methods: The stu...

It is suggested that radioiodine therapy in hyperthyroidism can increase mortality because of cardiovascular diseases. To determine that fact we have evaluated how the levels of predictors of the cardiovascular risk in serum such as: glucose, insulin, total cholesterol and high-density cholesterol, low-density cholesterol and triglycerides as well as CRP, fibrinogen and D-dimers changed in hyperthyroidism cases before and 12 up to 16 and 24 up to 28 weeks after radioiodine the...

Introduction: Metformin (MET) is mainly used in diabetes mellitus type 2 (DM2) therapy. Little is known about its effects in patients with metabolic syndrome (MS) and insulin resistance (IR) without DM2.Aim: To asses the influence of MET on carbohydrate metabolism in young prediabetic women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M1) and after (M2) ME...

Introduction: Metabolic syndrome (MS) is connected to atherogenic dyslipidemia. Data concerning influence of metformin (MET) therapy on lipid profile in nondiabetic women with MS remains unclear.Aim: To asses the influence of MET on selected lipid, apolipoproteins AI, B concentrations and atherogenic indexes values in young women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M<s...

Introduction: Results of many studies indicate that BsmI polymorphism in VDR gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of glucocorticoid-induced osteoporosis.Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI) and its relationship to phenotypic features characterizing bone status (BMD and metabolic bone turnover).Material and methods: Followin...