Endocrine Abstracts

We already know that woman with PCOS face increased risk of glucose intolerance, diabetes, metabolic syndrome and cardiovascular disease. However, it seems that it doesn’t apply to all women with PCOS and depends on their phenotypes.Aim of the study: Evaluation of tissue glucose utilization and lipid’s profile in different PCOS phenotypes.Materials and Methods: 69 PCOS women were divided into ten phenotypes groups, accord...

Results of several clinical studies have suggested that there is an excess risk of cardiovascular disease in persons with vitamin D deficiency.We examined association between serum levels of vitamin D - 25(OH)D and select cardiovascular risk factors in 254 postmenopausal women at a mean age of 55.38±205 years.Vitamin D levels, lipoproteins, TNF-α, Interleukin 6, adiponectin, insulin (using RIA methods) and glucose were as...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most commonly diagnosed endocrinopathies in women of reproductive age and is associated with an increasing number of metabolic comorbidities. About 50% of PCOS patients are obese, while insulin resistance affect up to 70% of these women. The endocannabinoid system contributes to human energy homeostasis. CNR1 is a biological candidate for human obesity and related metabolic disorders.Aims: The ...

Background: Hyperthyroidism is a common endocrine disorder that is linked to increased cardiovascular morbidity and mortality. Thrombospondin, the matricellular protein, is an important player in the process of cardiac remodelling with complex effects on cardiovascular disease (e.g. prothrombotic and antiangiogenic effects vs potential protective effects in heart failure). Adiponectin is an adipose tissue-derived hormone that shows beneficial effects on atherogenesis, endothel...

Recently, low serum adiponectin levels is created as a new risk factor for cardiovascular diseases in climacteric women. Our previous study shows that smoking, serum testosterone levels, blood pressure and BMI have the influence on serum adiponectin levels. Endocannabinoid system plays a role in regulation of food intake and fat accumulation, as well as lipid and carbohydrate metabolism. Menopause transition is related to metabolic disorders (e.g. obesity) and cause the increa...

Introduction: Mechanisms by which visceral obesity and insulin resistance (IR) contribute to atherogenesis are complex and not entirely known. One of the atherogenic factors involved in foam cells formation is scavenger receptor CD36 expressed on monocytes, endothelial cells, adipocytes and platelets, participating in oxidized LDLs absorption and foam cells formation – processes that initiate atheroslerosis. Many factors can influence the expression of receptor CD36.<...

Background/Aims: Calcium and vitamin D malabsorption in celiac disease predispose to skeletal demineralization. The aim of this study was to evaluate the prevalence of bone mineral density (BMD) and calcium deficiencies in adult patients with CD and assess whether a gluten-free diet is sufficiently effective for BMD restoration or whether calcium and vitamin D should be applied.Methods: BMD and biochemical parameters of bone and mineral metabolism were m...

Introduction: Results of many studies indicate that the BsmI and FokI polymorphisms in the VDR gene may influence bone tissue metabolism and may be useful in means of identifying patients at greater risk of osteoporosis.Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI and FokI) and its relationship to phenotypic features characterizing bone status (BMD).Materials and methods: 176 randomly selected ...

Introduction: It was found that vitamin D could have a direct effect of on adipocyte differentiation and metabolism and might be involved in glucose regulation of insulin secretion, which may be speculated from finding of a nuclear localization of 1,25-(OH)2D3 in the pancreatic islets. In recent years several polymorphisms in VDR gene, which are potent to alter the activity of VDR protein, have been described. BsmI and FokI polymorphisms were described in...

Introduction: Visfatin belongs to adipokines, i.e. hormones produced mainly by adipose tissue; its expression and role have been described in many organs, where it regulates energy metabolism, insulin resistance and inflammatory reactions. Moreover, the level of visfatin changes during pregnancy and in obese women and those with obesity related pregnancy pathologies: preeclampsia (PE), gestational diabetes (GDM) or intrauterine growth restriction (IUGR) its level increases. Th...