Endocrine Abstracts

A middle age barrister admitted via accident and emergency department with the history of dyspnoea on exersion, orthopnoea,palpitation, weight loss and significantly reduced exercise tolerance to an extent he was not able to walk more than few metres. He had been investigated for tuberculosis and treated for chronic alcohol excess in the past, there was no history of ischaemic heart disease. He was not on any regular medication.Clinical examination revea...

Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.<p class="abste...

Context: Acromegaly can be complicated by cardiomyopathy. Treatment with somatostatin analogs has been shown to improve some cardiac parameters, but most published clinical trials involved few patients and were not randomized or controlled. In addition, their results are rather variable.Objective: To conduct a meta-analysis aimed at obtaining a more accurate picture of the effect of somatostatin analogs on the heart in patients with acromegaly.<p cla...

Objective and importance: Among pathologies associated with acromegaly, have great importance both colon benignant neoformations such polyposis, and cardiovascular complications such as miocardic hypertrophy, arterial hypertension, coronaropathy and valvulopathy.Clinical presentation: We report a case of 74-years-old woman with acromegaly, diabetes mellitus type II and hyperthyroidism, who was admitted at our clinic with symptoms of chronic febricula wit...

A 31-year-old Taiwanese lady presented with palpitations, anxiety, orthopnoea, peripheral oedema, diarrhoea and a swelling in her neck. She was taking no regular medication. Her paternal uncle had been treated for thyrotoxicosis. She smoked 20 cigarettes per day. Clinical examination revealed tachycardia (pulse rate between 115 and 150 beats/min), tachypnoea (respiratory rate 30 breaths/min), hypertension (BP 161/125 mmHg) and congestive cardiac failure. The thyroid gland was ...

Introduction Vascular adhesion protein-1 (VAP-1) is a known driver of hepatic inflammation and fibrosis, with elevated levels detected in the circulation in disease. We studied the tissue expression of VAP-1 in midgut NETs and carcinoid heart disease (CHD) alongside circulating soluble VAP-1 (sVAP-1) to determine the role of VAP-1 in NETs.Methods Expression of VAP-1 and inflammatory and stromal markers in midgut NETs tissue, CHD valves and control valves...

Introduction: FKBP prolyl isomerase 4, encoded by the gene FKBP4, is a member of the FK506-binding protein family and is presumed to be a regulator of the androgen receptor (AR) pathway. Mutations in FKBP4 have been proposed to cause Androgen Insensitivity Syndrome (AIS), with only one case reported in the literature so far.Aim: To report the clinical, biochemical and genetic findings in an infant with 46, XY DSD a homoz...

Case: An eighteen-year-old male was forwarded to our department by the ophthalmologist because of the resection of an angiomyxoma of the right eyelid. Medical history included multiple surgically excisions of myxomatous tumors from the skin (gluteal, scapular…). Clinical examination showed some lentiginous lesions on his back and more important clear stigmata of acromegaly (tall stature, wide nose, large hands…). Hence our suspicion of a syndromic disorder, in part...

Introduction: Thyroid hormones have an impact on the function and structure of the cardiac muscle.Aim: Investigate the prevalence and risk factors of structural and functional cardiac complications in patients with hyperthyroidism.Methods: We conducted a cross-sectional study on 30 patients with uncontrolled hyperthyroidism. Clinical, biological and therapeutic data were collected. A trans-thoracic echocardiography (TTE) and lung u...

A 36 years of old patient was admitted to the intensive care unit of cardiology when he experienced palpitations and orthopnea. The patient’s complaints started about 2 years ago as syncope and sudden shortness of breath. Thorax CT showed pleural effusion and increased cardiothoracic index. Findings on ECHO were : Ejection fraction 35%, severe mitral regurgitation and global hypokinesia. Coronary angiogram showed a fibrocalcific plaque noted in in the distal LAD. The pati...