Endocrine Abstracts

Ventricular septal defect (VSD) is a congenital heart malformation that has been identified as an abnormal communication between the ventricles. The defect can be found at any part of the septum. A large VSD allows unimpeded left-right shunt with subsequent development of pulmonary hypertension and shunt reversal. The shunt reversal leads to development of Eisenmenger syndrome. We present the case of 40-year-old female with ventricular septal defect with Eis...

Introduction: Primary hyperparathyroidism (PHPT) is typically characterized by elevated serum calcium associated with elevated or non-suppressed levels of parathyroid hormone (PTH). These biochemical features are both known to affect the cardiovascular (CV) system. There is a conflicting debate regarding the CV manifestations of PHPT. the aim of our study is to evaluate the cardiovascular profile in patients with PHPT.Methods: We conducted a retrospectiv...

Objective: Cardiovascular diseases are the most common comorbidities in acromegaly. Potential parameters in pathology of cardiovascular comorbidities are changes in levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) as well as body composition parameters.Purpose: The aim of this study was to examine morphological and functional parameters of the cardiovascular system by echocardiography and to assess its relationship with disease acti...

Background: Cabergoline-associated valvulopathy (CAV) is an established complication of cabergoline therapy in Parkinson’s disease, with a definitive echocardiographic triad of severe regurgitation, leaflet thickening, and restricted valve movement without calcification. Long-term cabergoline therapy is deemed safe for prolactinoma due to low dosage. We describe the first UK case report of aortic regurgitation (AR) associated with low-dose cabergoline in prolactinoma....

Aim: To study the morphofunctional state of the myocardium in young people with diabetes mellitus 1 using magnetic resonance imaging (MRI) technology.Material and methods: 38 patients (14 men, 24 women), aged 18–36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive mri of the heart. The exclusion criteria were: pronounced electrolyte disorders in the blood, dysproteinemia, chronic liver and kidney fail...

Introduction: Pre-thrombotic states may be primary, related to a hereditary coagulation disorder or secondary (venous stasis or drug intake). We report a case of hyperthyroidism revealed by pulmonary embolism.Observation: A 82-year-old woman, with a forty years history of type 2 diabetes mellitus, was admitted to the emergency room in a respiratory distress condition. The clinical examination found a dyspnoeic patient with tachycardia, hypertension, and ...

Introduction: Acromegaly is a rare chronic, and disfiguring endocrine disorder characterized by growth hormone excess, that carries a significant burden of cardiovascular morbidity and mortality; and still unfortunately one of the most important cause of death in acromegaly. The purpose of this study is to describe the cardiovascular events and risk factors concerning patients with acromegaly who are followed up in the endocrinology department of Oujda’s Mohammed VI unive...

The aim: To evaluate effectiveness of complex therapy in patients with comorbidity of type 2 diabetes (DM2) and essential hypertension (EH) depending on genetic polymorphism peroxisome proliferator-activating receptor-γ2 (PPARγ2). Before and after 3 months of treatment we examined 145 patients with EH stage II, grade and DM2 moderate, subcompensated aged 45–60 years: group 1 (71 patients) received standart therapy (telmisartan, indapamide, metformin, gliclazide,...

Introduction: Hyperthyroidism has been described as a rare cause of pulmonary hypertension (PH) as well as systemic arteriovenous fistulas. However, we describe a case of pulmonary hypertension secondary to an intrathyroid arteriovenous fistula, not previously described in the literature.Case report: A 56 year old woman followed in our consultations with multinodular goiter and a long standing hyperthyroidism, secondary to Graves Basedow disease with dif...

Background: Primary and secondary hyperparathyroidism (HP) are associated with increased risk for cardiovascular complications and high mortality. Risk factors correlated with hypertension in HP are hyperlipidemia, glucose intolerance, insulin resistance, vitamin D deficiency, etc. The aim of the study was to assess the incidence of cardiovascular complications in HP.Material and methods: The study included 45 patients (15 men, 30 women), with a mean age...