Endocrine Abstracts

Aim: The primary objective of this study was to evaluate the structural and functional cardiac parameters with MRI in patients with primary hyperparathyroidism (pHPT) before and after successful surgery.Method: In this prospective study 16 patients with pHPT were included. Detailed cardiac magnetic resonance imaging (MRI) examinations were performed preoperatively and at six months post-surgery. Following parameters were measured: Left ventricle ejection...

Background: Gaucher disease (GD) is the most prevalent lysosomal disorder caused by GBA mutations and abnormal glucocerebrosidase function, leading to glucocerebroside accumulation mainly in the liver, spleen, bone marrow, lungs, and occasionally in the central nervous system. Gaucher disease type 3c (GD3c) is a rare subtype of the subacute/chronic neuronopathic GD3, caused by homozygosity for the GBA p. Asp448His (D409H) mutation. Case...

Transient neonatal diabetes mellitus (TNDM) occurs in 50-60% of all cases of neonatal diabetes mellitus (NDM). The most common cause of TNDM (70%) is almost invariably associated with defect in chromosome 6 and mutations in the KCNJ11, ABCC8, INS, NHF1B etc. genes. TNDM is caused by mutations in the GATA6 gene in rare cases. This gene encodes a transcription factor that is important for the development of the hematopoietic, cardiac and gastrointestinal systems.<p ...

Case history: A 65 year old unresponsive female, admitted as a stroke call, was found to have myxoedema crisis with admission TSH level of >100 mIU/l and T4 of 0.7 pmol/l. She was known hypothyroid with poor medication compliance. ITU admission for intubation and ventilation, CVVH (renal filtration) and vasopressors was required. Total length of ITU stay was 62 days, prolonged by cardiac complications during correction. There was no known cardiac history. On Day 7 of admission...

Case history: We present the case of a 70-year-old female who presented to the Emergency Department with sudden onset inter-scapular and upper abdominal pain. She had been experiencing intermittent headaches, palpitations and constipation which had not previously been investigated. The only past medical history was of hypothyroidism. She had no significant family history. There was a discrepancy in the blood pressure between both arms. Admission blood pressure was elevated at ...

Introduction and aim: There are few side effects of cabergoline which is used for medical treatment of prolactinoma. For this reason, cabergoline is considered as first-line therapy of prolactinoma. However, chronic administration of high dose cabergoline in patients with prolactinoma may be associated with valvular heart disease. The aim of this study is to evaluate left ventricular systolic and diastolic functions by conventional and tissue Doppler echocardiography in patien...

Introduction: The aim of this study, left ventricular systolic and diastolic function by echocardiography and tissue Doppler echocardiographic evaluation and relationship serum N-terminal pro-B-type brain natriuretic peptide (NT-proBNP) levels of women with polycystic ovary syndrome (PCOS).Materials and method: Thirty-two women with PCOS (age: 23.4–4.6 years; BMI: 23.8–4.8 kg/m2), similar age and BMI have features 30 healthy womens c...

Background: Vascular adhesion protein-1 (VAP-1) is a novel driver of tissue inflammation and fibrosis and may contribute to fibrotic complications of neuroendocrine tumours (NETs). We studied the VAP-1 expression in midgut NETs, which are associated with desmoplasia, and carcinoid heart disease (CHD), a significant complication of metastatic midgut NETs.Methods: Immunohistochemical analysis of paraffin-embedded midgut NETs and CHD valves were stained for...

Background: Mineral and bone disorders in chronic kidney disease (CKD-MBD) is a systemic disorder of mineral metabolism due to CKD, which is manifestedby abnormalities of calcium, phosphorus, parathormone (PTH) and vitamin D; renal osteodystrophy; extraskeletal calcification. In patients with CKD, vascular calcification occurs 10–20 years earlier than in the general population, and is highly prevalent (40–92%) in the hemodialysis population. «AngioScan-01&#187...

Introduction: Acromegaly is a rare chronic disorder caused by growth hormone hypersecretion due to GH-producing pituitary adenoma. Surgery is the first-line treatment modality. However, patients with severe cardiac involvement are high-risk candidates for pituitary surgery. These patients may benefit from rapid preoperative biochemical control of acromegaly. There is emerging evidence of efficacy of pegvisomant, a GH-receptor antagonist, (either alone or in combination with so...