Endocrine Abstracts

Pancreatic neuroendocrine tumors (PETs) occurs in approximately 1 per 100 000 people per year and account for only 1–2% of all pancreatic tumors. Most of them are hormonally active, while about 30% secrete no detectable hormons and are discovered due to a tumor mass effect.Material and methods: We analysed 178 patients with neuroendocrine tumors (NETs) treated at our department in the last five years. The diagnosis was made by pathohistological exam...

Anorexia nervosa (AN) is a chronic disorder characterized of profound reduction in body weight and amenorrhoea. Despite emaciation and avoidance of cholesterol-rich food, hypercholesterolaemia is a common feature. The aim of the study was to investigate the changes in lipid metabolism with weight gain in 17 severe AN patients aged 23.8±1.6 years (DSM-IV criteria). They were compared with age-matched cohorts of 11 healthy controls (22.5±3.9 years) before and after wei...

Objectives: Insulin resistance and hyperinsulinaemia are implicated in the pathogenesis of the polycystic ovary syndrome (PCOS) in the majority of the cases. Adiponectin is adipose tissue-specific protein and its correlation with insulin resistance is well established. The aim of the study was to access the correlation between adiponectin and anthropometric and metabolic parameters in a group of women with PCOS.Methods: Thirty-one women with PCOS (age: 2...

Anorexia nervosa (AN) is associated with bone loss due to weight loss, decreased caloric intake, amenorrhoea and behavioral changes. The most important predictor of the occurrence of bone loss is body weight (BMI <16.5 kg/m2). Previous studies suggested that many factors including effects of chronic undernutrition in AN patients is associated with a reduction of bone formation (osteocalcin-OC) uncoupled with increased resorption markers (crosslaps-CTx). The aim ...

Mutation Y791F of RET protooncogene is a well known mutation so far described in families with FMTC and familial pheochromocytoma in one family. It activates the receptor in a monomeric form. Here we present eight unrelated families with the same mutation but different fenotype expression.Patients and methods: In last 20 years, we analyzed 216 patients with MTC (age range: 3–75 years, 45.0 mean). Genetic testing for mutation in RET pro...

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder. The metabolic aspect of disorder is characterized by obesity-related risk factors for cardiovascular disease. The aim of this study was to determine in women with PCOS, indices of lipid metabolism and their oxidation, and to assess possible relation to insulin resistance. We investigated 75 women with PCOS (age: 23.1±5.1 years, body mass index (BMI): 24.9±4.7 kg/m2) and 56 age an...

We describe a 52-year-old woman, with acromegaly, clival chondroid chordoma, meningioma and lung carcinoid. There was no family history of MEN-1. She was diagnosed as acromegaly in 2000. Radiological evaluation (MRI) revealed pituitary tumor, however, another infiltration of scull base was detected which invaded sphenoidal and ethmoidal sinuses, lamina cribroza and bilateral orbit walls. Pituitary tumor was completely removed and the reduction of extra-sellar mass was performe...

The diagnosis of adult growth hormone deficiency (GHD) in patients with pituitary disease relies predominantly on provocative tests of GH secretion. The incidence of GHD in treated acromegalic patients has not been fully documented. Therefore, the aim of the present study was to elucidate GH response to insulin-induced hypoglycaemia (ITT, 0.15 IU/kg i.v.) in a cohort of 10 patients with acromegly considered cured solely by transsphenoidal surgery (6 females and 4 males, mean a...

The aim of this study was to compare metabolic profile in hypertensive obese and lean subjects. The study population consisted of 76 patients. We measured fasting glucose and insulin levels, triglycerides, total, LDL and HDL cholesterol. We also estimated the BMI, WHR, systolic (SBP) and diastolic blood pressure (DBP). We used WHO criteria for abdominal obesity (WHR>0.90 men, >0.85 women), and WHO criteria for diagnosing the metabolic syndrome (triglyceride>1.7 mmo...

The short-term results of transsphenoidal surgery as initial treatment for acromegaly were analyzed according to consensus defining the criteria for cure of acromegaly.Thirty nine newly diagnosed patients with acromegaly (20 females and 19 males, mean age 46.9 plus/minus 1.4 years, range 29-66 yrs), underwent transsphenoidal pituitary adenomectomy by the same neursurgeon. Patients have been assessed postoperatively at 8 weeks (GH after 75 g oral glucose ...