Endocrine Abstracts

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

Introduction: Acromegaly is a rare chronic disease characterized by systemic comorbidity. As a chronic disease, which in most cases requires long-term treatment, it is often accompanied by musculoskeletal, metabolic, and cardiovascular diseases, as well as headaches, anxiety, and depression, which leads to impaired quality of life.Aim: Assessment of quality of life in patients with acromegaly compared to healthy controls.Materials ...

Introduction: Previous studies reported increased unfavorable metabolic phenotype in patients with active acromegaly.Aim of the study: We studied the metabolic phenotype in unselected cohort of 133 patients with active acromegaly (83 female, 62.4%), diagnosed at Clinic of Endocrinology, University Clinical Center, Belgrade, Serbia in the period 2007–2018. Mean age at diagnosis of acromegaly was 50.5±1.2 years and mean BMI was 28.4±0.4 kg/m...

Introduction: Skeletal complications of acromegaly are among its most persistent and invalidating impacts. Dual-X-ray absorptiometry (DXA) alone might be insufficient or even misleading for bone health assessment in acromegaly.Patients and methods: Patients with acromegaly (N=170) were classified as active (N=104), operatively cured (N=34) or medically controlled (N=32). 57 males and 113 females were included, 52.8 (22...

Introduction: Insulin resistance and obesity are common features of polycystic ovary syndrome (PCOS) and both are independently associated with dysglycaemia. The aim of this study was to determine prevalence of dysglycaemia in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We evaluated 100 obese women with PCOS (PCOS group: 28.99±3.05 kg/m2; 27.70±5....

Introduction: Metabolic syndrome (MS) is an independent risk factor of coronary artery disease (CAD). We investigated how influenced this risk is by the definition of MS, and whether the risk is greater than that conferred by its components.Methods: We analyzed 200 consecutive patients (35–79 years, mean 59.23±8.6, men 132, women 68) who underwent coronary angiography due to suspected myocardial ischemia. MS was obtained by several definitions:...

Adrenocortical carcinoma (ACC) is rare and aggressive malignancy with poor prognosis. Patients present with hormone excess or a local mass effect, or incidentally. ACC has undergone metastatic spread in 40–70% of patients at the time of diagnosis. Surgical removal is treatment of choice. Standard chemotherapy with mitotane has limited efficacy.The aim of this paper is to present the results of single tertiary center for diagnosis and treatment of AC...

Introduction: Multiple endocrine neoplasia type 1 syndrome (MEN1sy.) is a complex disease predisposing to a variety of multifocal neuroendocrine tumors (NET). Approximately 5% of pancreatic VIPomas and glucagonomas are associated with MEN1sy., most of them with metastases at diagnosis.Case report: A 15-year-old boy was admitted with primary hyperparathyroidism, pituitary microadenoma (6 mm) and suspected MEN1sy. His father had primary hyperparathyroidism...

Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease which is characterized with dysregulation of the immune system. Recent studies suggest that dysregulation of the HPA axis may as well play a contributory role in the pathogenesis of RA. Glucocorticoid hormones (GC) accomplish their effects through binding to glucocorticoid receptor (GR). Presence of GR gene polymorphisms can modulate GC effects. The A3669G polymorphism in human GR gene has been connected...

Ghrelin is a somatotrophic, orexigenic and adipogenic hormone that has an important homeostatic role by linking regulatory systems for growth and energy balance. Ghrelin- secreting neuroendocrine tumors are rare, but we had the opportunity to study a 71 years old female patient with a gastric ghrelinoma. The patient was submitted to gastroenterological examination after having episodes of diarrhea, and small subepithelial polyp (5 mm) was revealed on gastroscopy. Pathohystolog...