Endocrine Abstracts

Case history: A 54-year-old man was admitted with a history of syncopal episodes. Orthostatic hypotension led to an endocrine referral and subsequent diagnosis of pan-anterior hypopituitarism but with no evidence of posterior pituitary involvement. Although an initial aetiological diagnosis remained elusive, further work-up (see below) led to a histology-confirmed diagnosis of ACE-negative neurosarcoidosis. This diagnostic conundrum could have been contributed by a prior neuro...

Introduction: Phaeochromocytoma (PHAEO) and paraganglioma (PGL) are neuroendocrine tumors arising from neural crest-derived cells either in the adrenal gland (PHAEO) or along the central sympathetic and parasympathetic chains (PGL), including the carotid body. There is convincing evidence linking hypoxia pathways with development of PHAEO/PGL especially with genetic susceptibility. Association between PHAEO and PGL and cyanotic congenital heart disease (CHD) are well recognise...

Background: Evidence shows relative adrenal insufficiency is one of the complications known to be associated with major procedures such as cardiopulmonary bypass surgery or critical illness. This is the first case we are presenting someone with acute hypoadrenalism following post thrombin injection to treat pheudoaneurysms.Case: We present an interesting case of 55 years old man with known decompensated alcoholic liver disease with oesophageal varices, p...

Introduction: Adrenal incidentalomas are increasingly found in patients imaged for investigation. A service evaluation was undertaken to standardise care for these patients in line with the European Society of Endocrinology Guidelines.Aim: Standardise the care for patients with adrenal adenomas at Royal Liverpool University Hospital.Method: Retrospective review of 70 patients with adrenal incidentalomas over 2 years (January 2016&#...

Introduction: Adrenal incidentalomas are common occurrence with up to 3–10% of the general population who have imaging. Up to 20% of them may have autonomous cortisol secretion (ACS), a term that refers to biochemical evidence of excess cortisol, but without the overt cushing’s syndrome.Aim: Prevalence of ACS in our cohort of patients with adrenal incidentalomas and review their care.Method: Retrospective review of 70 pat...

Pseudohypoparathyroidism (PHP) is highly heterogeneous rare disorder characterized by end organ resistance to PTH action with proven genetic component. PHP-Ib classically refers to a condition characterized by renal resistance to PTH in the absence of other endocrine or physical abnormalities and in the presence of a normal GNAS alfa activity and only few cases have been reported so far. We report a case of 43 year old gentleman was diagnosed to have seizures at the age of 13 ...

Prolactinomas are the most common hormone-secreting pituitary tumors. They typically present with hypogonadism, decreased libido, infertility, and gynaecomastia in men. We present an interesting case of a 44-year-old gentleman who was referred to our endocrine clinic for ‘abnormal thyroid function tests’ with a low T4 despite a normal TSH (TSH 2.01, T4 7.5, T3 3.9). He reported a few years’ history of increasing weight gain and lethargy, generalized aches and pa...

Current systemic treatments are not satisfying for the treatment of adrenocortical carcinoma (ACC). However, translation of preclinically promising approaches were often disappointing indicating that existing tumor models might have inadequately predicted clinical applicability. Thus, our workgroup initiated a comparative drug screen of relevant chemotherapies and therapies targeting IGFR, EGFR, VEGFR/PDGFR and Wnt signalling pathway in the classical NCI-H295R and recently dev...

MEN1 is an autosomal dominant endocrine tumour syndrome, caused by inactivating mutations of the MEN1 tumour suppressor gene at 11q13 locus and characterised by occurrence of hyperparathyroidism, pancreatic tumours and pituitary adenomas. We describe a family with MEN1 syndrome. The index case was a 71-year-old man, referred to Endocrinology clinic in Midland Regional Hospital Portlaoise for hypercalcemia (calcium 3 mmol/l, phosphate 0.5 mmol/l, PTH 350 pg/ml, creatin...

Introduction: DHEAS is weak androgen with specific role in human physiology illdefined. Various studies have implicated role of DHEAS in autoimmune arthritis including SLE and RA. Recently EULAR consensus statement has approved CSA (clinically significant arthralgia) for incipient RA.Methods and material: 34 follow up patients of primary hypothyroidism rated their symptom score on CSA (clinically suspect arthralgia) as given by EULAR(1) Their DHEAS level...