Endocrine Abstracts

Augmented pervasiveness of type 2 diabetes mellitus and obesity has amplified the medical necessitate for new agents to treat these disease states. Both type 2 diabetes and obesity are connected to the resistance to the hormones insulin and leptin. Protein tyrosine phosphatase 1B (PTP1B) has been shown to function as negative regulator of insulin signalling as well as leptin signal transduction. At present there are copious compounds synthesized as PTP1B inhibitors. The develo...

Introduction: Available clinical literature raises the possibility that stress-responsive mechanisms differ by gender, especially in older individuals; however the accompanying evidence is both limited and discrepant. We hypothesize that gender determines the degree of ACTH inhibition by and recovery after an experimental cortisol clamp in older subjects.Subjects and design: We conducted a prospectively randomized, double-blind, placebo-controlled, cross...

We are living in the electronic era and day to day exposed by estrogenic disruptors such as Bisphenol-A (BPA). Electronic gadgets such as cellular phones, CDs, DVDs, RFIDs even baby feeding bottles are made with composition of BPA and their huge application are matter of debate in present. The chronic exposures of BPA have become a major health concern. In this study we assessed the neurobehavioral alterations caused by BPA in the rats. We examined the neurobehavioral changes ...

Temporary hypocalcaemia following total thyroidectomy occurs in around 30% of patients and is usually due to inadvertent damage to the parathyroid glands. Whilst mild cases are easily managed with oral calcium supplementation, there is the potential for severe calcium deficit with the ensuing risks of cardiac dysrhythmias, tetany and in extreme cases death. It is common practice to have a post-surgery protocol to allow the early identification of these patients. Whilst many pr...

Back ground: Acute adrenal insufficiency is a life threatening condition with multiple aetiologies. The adrenal gland is susceptible to thrombosis and hemorrhagic infarction due to rich arterial supply and limited venous drainage. We present a case report of a simultaneously detected acute adrenal insufficiency due to bilateral adrenal haemorrhagic infarcts with ischemic bowel as the first manifestation of antiphospholipid syndrome (APS).Case history: A ...

Background: Idiopathic intracranial hypertension (IIH) can rarely be associated with underlying endocrine disorders such as Cushing’s syndrome, hyperthyroidism or with administration of thyroxin or growth hormone. We describe a case of acute adrenal deficiency presented along with IIH.Case history: A 24-year-old Caucasian female (body mass index 21 kg/m2) presented with nausea, vomiting and collapse. She had several months of generalised ...

Diabetes mellitus like all chronic illnesses requires lifelong management (self or guided) with regular health professional support and supervision. Non-attendance at outpatient clinics (OPD) is a common cause of inefficiency in our current health care system causing undue wastage of clinician time and resources and potentially lengthening waiting times.Aim: The aim of our pilot project was to improve our diabetes OPD from the current attendance of 78% t...

Objective: Premixed aspart is being used in once, twice and thrice-daily regimes in persons with diabetes. This study was designed as a cross-sectional, observational study to assess the need for three-dose premixed aspart in different subsets of subjects with type 1 and type 2 diabetes attending an endocrine OPD.Methods: Records of 200 consecutive patients receiving premixed insulin were assessed to determine the frequency of insulin dosage and its clin...

Introduction: Despite the significant associated cardiovascular morbidity, as well as the significant economic implications, little consideration has been given towards population screening for the Metabolic Syndrome (MetS). Therefore, we wished to estimate the prevalence of MetS, using both the recently published IDF, as well as the previously defined Cholesterol Education Program Adult Treatment Panel III (ATPIII), criteria. Additionally, we hypothesised that simple, inexpen...

Introduction: The presence of Metabolic Syndrome (MetS) may be associated with increased cardiovascular risk. The International Diabetes Foundation (IDF) has recently published new diagnostic criteria for MetS. Thus, we sought to compare IDF-defined MetS, the previously defined Cholesterol Education Program Adult Treatment Panel III (ATPIII) and the European SCORE risk stratification model as predictors of the presence of Ischaemic Heart Disease (IHD) within an asymptomatic po...